加德满都三轮车出租车司机血清促红细胞生成素与血铅浓度之间的负相关关系。
Inverse relationship between serum erythropoietin and blood lead concentrations in Kathmandu tricycle taxi drivers.
作者信息
Sakata Susumu, Shimizu Satoshi, Ogoshi Kumiko, Hirai Kazuko, Ohno Yoshimi, Kishi Takashi, Sherchand Jeevan B, Utsumi Masako, Shibata Munetaka, Takaki Miyako, Ueda Masatsugu, Mori Ippei
机构信息
Department of Physiology II, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan.
出版信息
Int Arch Occup Environ Health. 2007 Feb;80(4):342-5. doi: 10.1007/s00420-006-0125-4. Epub 2006 Jul 13.
OBJECTIVE
Kathmandu tricycle taxi drivers, whose environmental lead (Pb) exposure is ascribable mainly to vehicular exhaust, were studied to examine a dose-response relationship between blood Pb (Pb-B) and serum erythropoietin (sEPO) concentrations.
METHODS
Subjects were 27 drivers and 9 non-drivers. They were non-anemic healthy men with normal renal function. Pb-B was measured by an atomic absorption spectrometer with a graphite furnace, and sEPO was determined with a sandwich-type enzyme-linked immunosorbent assay.
RESULTS
sEPO levels in drivers were lower than those of non-drivers, while Pb-B levels in drivers were higher than those of non-drivers. There was an inverse relationship between Pb-B and sEPO.
CONCLUSIONS
The data suggest that Pb inhibits renal EPO production in a dose-dependent manner in persons with subclinical Pb toxicity. sEPO may serve as an early biochemical marker of subclinical Pb toxicity.
目的
加德满都三轮车出租车司机的环境铅（Pb）暴露主要归因于车辆尾气排放，本研究旨在探讨血铅（Pb-B）与血清促红细胞生成素（sEPO）浓度之间的剂量反应关系。
方法
研究对象为27名司机和9名非司机。他们均为肾功能正常的非贫血健康男性。采用石墨炉原子吸收光谱仪测定血铅，采用夹心型酶联免疫吸附测定法测定血清促红细胞生成素。
结果
司机的血清促红细胞生成素水平低于非司机，而司机的血铅水平高于非司机。血铅与血清促红细胞生成素之间呈负相关。
结论
数据表明，在亚临床铅中毒患者中，铅以剂量依赖的方式抑制肾脏促红细胞生成素的产生。血清促红细胞生成素可能作为亚临床铅中毒的早期生化标志物。
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