Betal S, Bose S M, Biswas N, Mitra H
Department of Anaesthesiology, Calcutta National Medical College.
J Indian Med Assoc. 1991 Jun;89(6):169-70.
The drug vecuronium bromide, a short acting, non-depolarising agent with little side-effects, has brought much promise in the field of muscle relaxants. Fifth healthy patients were induced with injection thiopentone sodium 4 mg/kg and vecuronium bromide, 0.1 mg/kg was given IV. The earliest time at which the largest percentage of patients could be intubated satisfactorily was noted. The intubating conditions were estimated by scoring method. The duration of clinical relaxation was decided from the time of IV injection of vecuronium bromide to the return of muscle power of the non-respiratory muscles requiring repeat dose of the drug. The ideal intubating condition was achieved at 120 seconds and the duration of clinical relaxation ranged from 11-15 minutes.
药物维库溴铵是一种短效、非去极化剂，副作用小，在肌肉松弛剂领域带来了很大希望。五名健康患者静脉注射4mg/kg硫喷妥钠进行诱导，并静脉注射0.1mg/kg维库溴铵。记录能使最大比例患者满意插管的最早时间。通过评分方法评估插管条件。临床松弛持续时间从静脉注射维库溴铵之时起，至非呼吸肌肌力恢复需要重复给药的时间。120秒时达到理想插管条件，临床松弛持续时间为11 - 15分钟。
