Lassmann Timo, Sonnhammer Erik L L
Center for Genomics and Bioinformatics, Karolinska Institutet, S-17177 Stockholm, Sweden.
Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W596-9. doi: 10.1093/nar/gkl191.
Obtaining high quality multiple alignments is crucial for a range of sequence analysis tasks. A common strategy is to align the sequences several times, varying the program or parameters until the best alignment according to manual inspection by human experts is found. Ideally, this should be assisted by an automatic assessment of the alignment quality. Our web-site http://msa.cgb.ki.se allows users to perform all these steps: Kalign to align sequences, Kalignvu to view and verify the resulting alignments and Mumsa to assess the quality. Due to the computational efficiency of Kalign we can allow users to submit hundreds of sequences to be aligned and still guarantee fast response times. All servers are freely accessible and the underlying software can be freely downloaded for local use.
获得高质量的多序列比对对于一系列序列分析任务至关重要。一种常见策略是多次比对序列，改变程序或参数，直到找到根据人类专家人工检查得出的最佳比对。理想情况下，这应由比对质量的自动评估来辅助。我们的网站http://msa.cgb.ki.se允许用户执行所有这些步骤：使用Kalign进行序列比对，使用Kalignvu查看和验证结果比对，以及使用Mumsa评估质量。由于Kalign的计算效率，我们可以允许用户提交数百个序列进行比对，并且仍然保证快速响应时间。所有服务器均可免费访问，底层软件也可免费下载以供本地使用。
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