磷酸肌醇3激酶类别概览。
Classes of phosphoinositide 3-kinases at a glance.
作者信息
Jean Steve, Kiger Amy A
机构信息
Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0380, USA.
出版信息
J Cell Sci. 2014 Mar 1;127(Pt 5):923-8. doi: 10.1242/jcs.093773.
Abstract
The phosphoinositide 3-kinase (PI3K) family is important to nearly all aspects of cell and tissue biology and central to human cancer, diabetes and aging. PI3Ks are spatially regulated and multifunctional, and together, act at nearly all membranes in the cell to regulate a wide range of signaling, membrane trafficking and metabolic processes. There is a broadening recognition of the importance of distinct roles for each of the three different PI3K classes (I, II and III), as well as for the different isoforms within each class. Ongoing issues include the need for a better understanding of the in vivo complexity of PI3K regulation and cellular functions. This Cell Science at a Glance article and the accompanying poster summarize the biochemical activities, cellular roles and functional requirements for the three classes of PI3Ks. In doing so, we aim to provide an overview of the parallels, the key differences and crucial interplays between the regulation and roles of the three PI3K classes.
摘要
磷酸肌醇3激酶（PI3K）家族对细胞和组织生物学的几乎所有方面都很重要，并且是人类癌症、糖尿病和衰老的核心。PI3K在空间上受到调控且具有多功能，它们共同作用于细胞内几乎所有的膜，以调节广泛的信号传导、膜运输和代谢过程。人们越来越认识到三种不同PI3K类别（I、II和III）以及每类中不同亚型各自独特作用的重要性。当前存在的问题包括需要更好地理解PI3K调控和细胞功能在体内的复杂性。这篇“一目了然的细胞科学”文章及随附的海报总结了三类PI3K的生化活性、细胞作用和功能需求。在此过程中，我们旨在概述三类PI3K在调控和作用方面的相似之处、关键差异及重要相互作用。
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