Shcharbin Dzmitry, Drapeza Alexander, Loban Valeri, Lisichenok Alexej, Bryszewska Maria
Department of General Biophysics, University of Łódź, Łódź, Poland.
Cell Mol Biol Lett. 2006;11(2):242-8. doi: 10.2478/s11658-006-0018-2.
The BLM-system for studying the electrophysical properties of bilayer lipid membranes (BLM) was applied to investigate interactions between polyamidoamine (PAMAM) dendrimers and lipid bilayers. The cationic PAMAM G5 dendrimer effectively disrupted planar phosphatidylcholine membranes, while the hydroxyl PAMAM-OH G5 and carboxyl PAMAM G4.5 dendrimers had no significant effect on them.
用于研究双层脂质膜(BLM)电物理性质的BLM系统被应用于研究聚酰胺-胺(PAMAM)树枝状大分子与脂质双层之间的相互作用。阳离子型PAMAM G5树枝状大分子有效地破坏了平面磷脂酰胆碱膜,而羟基化的PAMAM-OH G5和羧基化的PAMAM G4.5树枝状大分子对其没有显著影响。