猫疑似与克林霉素相关的食管损伤：5例报告
Suspected clindamycin-associated oesophageal injury in cats: five cases.
作者信息
Beatty Julia A, Swift Nigel, Foster Darren J, Barrs Vanessa R D
机构信息
Valentine Charlton Cat Centre, Faculty of Veterinary Science, University of Sydney, NSW 2006, Australia.
出版信息
J Feline Med Surg. 2006 Dec;8(6):412-9. doi: 10.1016/j.jfms.2006.04.006. Epub 2006 Jul 18.
The clinical findings, treatment and outcome of suspected clindamycin-associated oesophageal injury in five cats are reported. All cats were treated with one 75 mg clindamycin capsule twice daily (dose range 12-19 mg/kg). Capsules were administered without food or a water bolus. Dysphagia, regurgitation, choking or gagging were seen 3-9 days after starting clindamycin. On oesophagoscopy, three cats had oesophagitis, one of which progressed to stricture formation. Two cats had an oesophageal stricture at first presentation. This is the first report of suspected clindamycin-associated oesophageal injury in cats. It serves to further alert practitioners to the potential for drug-induced oesophageal disorders (DIOD) in cats treated with oral medications and to urge prevention by promoting a change in dosing practices.
本文报告了五只猫疑似克林霉素相关食管损伤的临床症状、治疗及预后情况。所有猫均每日两次口服一粒75毫克克林霉素胶囊（剂量范围为12 - 19毫克/千克）。给药时未同时给予食物或大量饮水。在开始使用克林霉素后3 - 9天出现吞咽困难、反流、呛咳或作呕症状。经食管镜检查，三只猫患有食管炎，其中一只发展为食管狭窄。两只猫在初次就诊时即发现食管狭窄。这是关于猫疑似克林霉素相关食管损伤的首例报告。旨在进一步提醒从业者，在用口服药物治疗的猫中存在药物性食管疾病（DIOD）的可能性，并敦促通过改变给药方式进行预防。
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