Karabatsou K, Pal P, Dodd S, Mat A, Haylock B, Aguirreburualde M, Moxam N, Pinson-Ellis W, Broome J, Rainov N G
Department of Neurosurgery, The Walton Centre for Neurology and Neurosurgery NHS Trust, L9 7LJ, Liverpool, UK.
J Neurooncol. 2006 Sep;79(2):171-9. doi: 10.1007/s11060-005-9102-0. Epub 2006 Jul 19.
Primary central nervous system lymphomas (PCNSL) are rare tumours occurring in the brain. Their biology and the factors predicting survival are not well known. This study investigated expression of the antiapoptotic protein survivin and platelet-derived growth factor A (PDGF-A) and receptor (PDGFRalpha) in PCNSL.
A total of 44 patients with histologically confirmed PCNSL treated between 1992 and 2004 were included in this study, and tumour specimens were investigated immunohistochemically for expression of survivin, PDGF-A and PDGFRalpha. Protein expression and clinical variables were analyzed statistically.
Of the 44 tumours 43(98%) were diffuse large B-cell non-Hodgkin's lymphomas (NHL) and one was a T-cell NHL. Around 37 (84%) of the examined PCNSL specimens showed expression of survivin, 16 (36%) of PDGF-A and 34 (77%) of PDGFRalpha. Tumours expressing surviving co-expressed PDGFRalpha frequently and PDGF-A occasionally. Expression of the above proteins was not predictive for survival in this patient group. Except for age and therapy, no other clinical variables correlated significantly with overall survival.
PCNSL express survivin and PDGFRalpha in the majority of investigated cases. PDGF-A is expressed less frequently. Immunohistochemical detection of these proteins does not correlate with overall survival and cannot be used as a prognostic factor.
原发性中枢神经系统淋巴瘤（PCNSL）是发生于脑内的罕见肿瘤。其生物学特性及预测生存的因素尚不清楚。本研究调查了抗凋亡蛋白survivin和血小板衍生生长因子A（PDGF-A）及其受体（PDGFRα）在PCNSL中的表达情况。
本研究纳入了1992年至2004年间44例经组织学确诊的PCNSL患者，对肿瘤标本进行免疫组织化学检测，以研究survivin、PDGF-A和PDGFRα的表达情况。对蛋白表达和临床变量进行统计学分析。
44例肿瘤中，43例（98%）为弥漫性大B细胞非霍奇金淋巴瘤（NHL），1例为T细胞NHL。在检测的PCNSL标本中，约37例（84%）显示survivin表达，16例（36%）显示PDGF-A表达，34例（77%）显示PDGFRα表达。表达survivin的肿瘤常同时表达PDGFRα，偶尔也表达PDGF-A。在该患者组中，上述蛋白的表达不能预测生存情况。除年龄和治疗外，无其他临床变量与总生存显著相关。
在大多数研究病例中，PCNSL表达survivin和PDGFRα。PDGF-A表达频率较低。这些蛋白的免疫组织化学检测与总生存无关，不能用作预后因素。
