轻度认知障碍和阿尔茨海默病的脑电图与磁共振成像相关性
EEG and MRI correlates of mild cognitive impairment and Alzheimer's disease.
作者信息
van der Hiele K, Vein A A, van der Welle A, van der Grond J, Westendorp R G J, Bollen E L E M, van Buchem M A, van Dijk J G, Middelkoop H A M
机构信息
Department of Neurology, Neuropsychology and Clinical Neurophysiology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.
出版信息
Neurobiol Aging. 2007 Sep;28(9):1322-9. doi: 10.1016/j.neurobiolaging.2006.06.006. Epub 2006 Jul 18.
OBJECTIVE
To investigate whether cognitive function in the spectrum of normal aging to Alzheimer's disease is better reflected in MRI or EEG measures, or a combination of both.
METHODS
Cognitive functions were tested in 33 elderly subjects: 10 with probable Alzheimer's disease, 11 with mild cognitive impairment and 12 controls. Structural brain parameters were derived from conventional MRI and a quantitative MR technique called magnetization transfer imaging. The EEG provided measures of brain function. We performed multiple linear regression analyses to relate EEG and MRI parameters to global cognition, memory, language and psychomotor speed.
RESULTS
The model showed EEG alpha reactivity during eyes open to be the primary factor associated with global cognition, memory and language skills. Brain atrophy was the primary factor associated with psychomotor speed. Furthermore, EEG alpha reactivity during eyes open explained significant additional variability in psychomotor speed.
CONCLUSION
EEG and MRI are each associated with different aspects of cognitive function and complement each other in their relations to psychomotor speed.
目的
研究在从正常衰老到阿尔茨海默病的范围内，认知功能在磁共振成像（MRI）或脑电图（EEG）测量中，还是在两者结合的测量中能得到更好的反映。
方法
对33名老年受试者的认知功能进行了测试：10名可能患有阿尔茨海默病，11名有轻度认知障碍，12名作为对照。大脑结构参数来自传统MRI和一种称为磁化传递成像的定量磁共振技术。脑电图提供了脑功能的测量指标。我们进行了多元线性回归分析，以将脑电图和MRI参数与整体认知、记忆、语言和精神运动速度联系起来。
结果
模型显示，睁眼时脑电图α反应性是与整体认知、记忆和语言技能相关的主要因素。脑萎缩是与精神运动速度相关的主要因素。此外，睁眼时脑电图α反应性解释了精神运动速度中显著的额外变异性。
结论
脑电图和磁共振成像分别与认知功能的不同方面相关，并且在与精神运动速度的关系中相互补充。
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