Werner Perla, Rosenblum Sara, Bar-On Gady, Heinik Jeremia, Korczyn Amos
Department of Gerontology, University of Haifa, Mt. Carmel, Haifa 31905, Israel.
J Gerontol B Psychol Sci Soc Sci. 2006 Jul;61(4):P228-36. doi: 10.1093/geronb/61.4.p228.
This study's aims were (a) to examine kinematically the handwriting process of persons with mild cognitive impairment (MCI), compared with those with mild Alzheimer's disease and healthy controls; (b) to assess the importance of these measures for the differentiation of the groups; and (c) to assess characteristics of the handwriting process across different functional tasks. Thirty-one persons with MCI, 22 with mild Alzheimer's disease, and 41 healthy controls performed functional tasks while using a computerized system. We found significant differences between the groups in almost all measures, with the MCI group assuming a position between the other groups. Temporal measures were higher and pressure was lower in more cognitively deteriorated groups. Information gathered about kinematic measures, together with cognitive functioning, allowed us to classify 69% to 72% of the participants correctly, although the classification for the MCI group was relatively poor.
(a) 与轻度阿尔茨海默病患者和健康对照者相比，从运动学角度检查轻度认知障碍（MCI）患者的书写过程；(b) 评估这些测量方法对区分不同组别的重要性；(c) 评估不同功能任务中书写过程的特征。31名MCI患者、22名轻度阿尔茨海默病患者和41名健康对照者在使用计算机系统时执行功能任务。我们发现，几乎所有测量指标在不同组之间都存在显著差异，MCI组处于其他两组之间。认知功能衰退越严重的组，时间测量值越高，压力越低。尽管对MCI组的分类相对较差，但结合运动学测量指标和认知功能所收集到的信息，使我们能够正确分类69%至72%的参与者。
