Yan Jin H, Rountree Susan, Massman Paul, Doody Rachelle Smith, Li Hong
Department of Kinesiology, California State University at East Bay, 25800 Carlos Bee Boulevard, Hayward, CA 94542-3062, USA.
J Psychiatr Res. 2008 Oct;42(14):1203-12. doi: 10.1016/j.jpsychires.2008.01.006. Epub 2008 Feb 15.
Sensory-motor dysfunctions are often associated with Alzheimer's disease (AD) or mild cognitive impairment (MCI). This study suggests that deterioration in fine motor control and coordination characterizes sensory-motor deficiencies of AD and MCI. Nine patients with a clinical diagnosis of probable AD, 9 amnestic MCI subjects and 10 cognitively normal controls performed four types of handwriting movement on a digitizer. Movement time and smoothness were analyzed between the groups and across the movement patterns. Kinematic profiles were also compared among the groups. AD and MCI patients demonstrated slower, less smooth, less coordinated, and less consistent handwriting movements than their healthy counterparts. The theoretical relevance and practical implications of fine motor tasks, such as these movements involved in handwriting, are discussed relative to the deteriorated sensory-motor system of AD and MCI patients.
感觉运动功能障碍常与阿尔茨海默病（AD）或轻度认知障碍（MCI）相关。本研究表明，精细运动控制和协调能力的下降是AD和MCI感觉运动缺陷的特征。9例临床诊断为可能AD的患者、9例遗忘型MCI受试者和10例认知正常对照在数位板上进行四种类型的手写运动。分析了组间以及不同运动模式下的运动时间和平滑度。还比较了组间的运动学特征。与健康对照相比，AD和MCI患者的手写运动更慢、更不流畅、协调性更差且一致性更低。相对于AD和MCI患者受损的感觉运动系统，讨论了诸如手写中涉及的这些运动等精细运动任务的理论相关性和实际意义。
