Tsukimori Kiyomi, Nakanami Naoyuki, Fukushima Kotaro, Yoshimura Takazumi, Hikino Shunji, Nakano Hitoo
Kyushu University, Fukuoka, Japan.
J Perinat Med. 2006;34(4):313-7. doi: 10.1515/JPM.2006.060.
To distinguish congenital chylothorax from other causes of hydrothorax in utero.
Serum and pleural fluid samples from 8 fetuses with congenital chylothorax and 5 control fetuses with other causes of hydrothorax were tested for total protein, albumin, IgG, IgA, and IgM.
Fetuses with congenital chylothorax had higher levels of IgG in pleural fluid, but not the other four proteins, than control fetuses (P<0.05). There were no significant differences in serum proteins among fetuses. When we examined pleural fluid to serum ratios, the IgG ratio in fetuses with congenital chylothorax was significantly higher than that of control fetuses (P<0.05). The IgG ratio in chylothorax was greater than 0.6 regardless of lymphocyte count.
Pleural fluid/serum IgG ratio may be a diagnostic marker for congenital chylothorax in utero.
在子宫内鉴别先天性乳糜胸与其他胸腔积液病因。
对8例先天性乳糜胸胎儿和5例因其他病因导致胸腔积液的对照胎儿的血清和胸腔积液样本进行总蛋白、白蛋白、IgG、IgA和IgM检测。
先天性乳糜胸胎儿胸腔积液中的IgG水平高于对照胎儿，但其他四种蛋白质水平无差异（P<0.05）。胎儿血清蛋白无显著差异。当我们检测胸腔积液与血清的比值时，先天性乳糜胸胎儿的IgG比值显著高于对照胎儿（P<0.05）。无论淋巴细胞计数如何，乳糜胸中的IgG比值均大于0.6。
胸腔积液/血清IgG比值可能是子宫内先天性乳糜胸的诊断标志物。
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