Granberg Fredrik, Svensson Catharina, Pettersson Ulf, Zhao Hongxing
Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, SE-751 85 Uppsala, Sweden.
Virology. 2006 Sep 15;353(1):1-5. doi: 10.1016/j.virol.2006.06.019. Epub 2006 Jul 24.
In this report, we have studied gene expression profiles in human primary lung fibroblasts (IMR-90) during the very early phase of an adenovirus infection. Eight out of twelve genes with known functions encoded transcription factors linked to two major cellular processes; inhibition of cell growth (ATF3, ATF4, KLF4, KLF6 and ELK3) and immune response (NR4A1 and CEBPB), indicating that the earliest consequences of an adenovirus infection are growth arrest and induction of an immune response. A time course analysis showed that the induction of these immediate-early response genes was transient and suppressed after the onset of the adenovirus early gene expression.
在本报告中，我们研究了腺病毒感染极早期人原代肺成纤维细胞（IMR-90）中的基因表达谱。在十二个已知功能的基因中，有八个编码与两个主要细胞过程相关的转录因子；细胞生长抑制（ATF3、ATF4、KLF4、KLF6和ELK3）和免疫反应（NR4A1和CEBPB），这表明腺病毒感染的最早后果是生长停滞和免疫反应的诱导。时间进程分析表明，这些立即早期反应基因的诱导是短暂的，在腺病毒早期基因表达开始后受到抑制。
