Takahashi R N, Karniol I G
Psychopharmacologia. 1975;41(3):277-84. doi: 10.1007/BF00428937.
The pharmacological activities of delta9-THC [(minus)-delta9-trans-tetrahydrocannabinol], CBN (Cannabinol) and mixtures of delta9-THC + CBN were studied in rabbits, rats and mice. CBN, although in general less active, mimicked the effects of delta9-THC in several pharmacological tests: corneal arreflexia in rabbits; climbing rope, open-field, irritability and aggressiveness after REM sleep deprivation in rats; catatonia, analgesia and sleeping time in mice. When the mixture delta9-THC + CBN was used, a synergistic effect occurred on most of the depressant effects. On the other hand CBN did not interfere with or slightly inhibited the excitatory effects of delta9-THC. In the one peripheral test used, CBN did not alter the delta9-THC effect.
研究了Δ⁹-四氢大麻酚[(-)-Δ⁹-反式-四氢大麻酚]、大麻酚（CBN）以及Δ⁹-四氢大麻酚与大麻酚的混合物在兔、大鼠和小鼠身上的药理活性。大麻酚虽然总体活性较低，但在多项药理试验中模拟了Δ⁹-四氢大麻酚的作用：兔角膜反射消失；大鼠攀爬绳索、旷场试验、快速眼动睡眠剥夺后的易怒性和攻击性；小鼠紧张症、镇痛和睡眠时间。当使用Δ⁹-四氢大麻酚与大麻酚的混合物时，对大多数抑制作用产生了协同效应。另一方面，大麻酚不干扰或轻微抑制Δ⁹-四氢大麻酚的兴奋作用。在一项外周试验中，大麻酚不改变Δ⁹-四氢大麻酚的作用。
