Roth B L
Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106.
Ann Clin Psychiatry. 1994 Jun;6(2):67-78. doi: 10.3109/10401239409148985.
Serotonin (5-hydroxytryptamine; 5-HT) has been implicated in a large number of psychophysiologic processes including the regulation of sleep, appetite, mood, aggression, perception, memory, and anxiety. To mediate this large array of physiologic processes, at least 14 separate 5-HT receptors have evolved, which are divided into seven main families. Not surprisingly, alterations of 5-HT receptor activity have been shown to occur in many psychiatric diseases including anxiety, depression, eating disorders, schizophrenia, personality disorders, and many drug-induced psychotic states. Additionally, a number of effective psychopharmacologic agents for diseases as diverse as schizophrenia and anxiety have been developed which either specifically alter brain levels of serotonin or bind to 5-HT receptor subtypes. This review article summarizes recent advances in the burgeoning field of serotonin receptor pharmacology and integrates this information into a coherent perspective on the importance of serotonergic agents for clinical psychiatry.
血清素（5-羟色胺；5-HT）与大量心理生理过程有关，包括睡眠、食欲、情绪、攻击性、感知、记忆和焦虑的调节。为介导这一系列生理过程，至少已进化出14种不同的5-HT受体，它们分为七个主要家族。毫不奇怪，5-HT受体活性的改变已被证明发生在许多精神疾病中，包括焦虑症、抑郁症、饮食失调、精神分裂症、人格障碍以及许多药物引起的精神状态。此外，已经开发出许多针对精神分裂症和焦虑症等多种疾病的有效精神药物，这些药物要么特异性地改变大脑中的血清素水平，要么与5-HT受体亚型结合。这篇综述文章总结了血清素受体药理学这一新兴领域的最新进展，并将这些信息整合到一个关于血清素能药物对临床精神病学重要性的连贯观点中。
