Deng Xiaohu, Mani Neelakandha S
Department of Drug Discovery, Johnson & Johnson Pharmaceutical R&D LLC, 3210 Merryfield Row, San Diego, California 92121, USA.
Org Lett. 2006 Aug 3;8(16):3505-8. doi: 10.1021/ol061226v.
A novel regioselective synthesis of substituted pyrazoles from N-monosubstituted hydrazones and nitroolefins is described. The reaction is performed in a one-pot manner and the yields range from moderate to excellent. A key nitropyrazolidine intermediate is characterized and a plausible mechanism is proposed.
描述了一种从N-单取代腙和硝基烯烃新颖的区域选择性合成取代吡唑的方法。该反应以一锅法进行，产率从中等至优异。对关键的硝基吡唑烷中间体进行了表征，并提出了合理的反应机理。
