CD8 + T淋巴细胞在艾滋病发病机制中的作用。
A role for CD8+ T lymphocytes in the pathogenesis of AIDS.
作者信息
Aranda-Anzaldo A
机构信息
Laboratoire d'Immunobiologie, Faculté de Médecine, Paris V.
出版信息
Res Immunol. 1991 Sep;142(7):541-50. doi: 10.1016/0923-2494(91)90099-5.
Abstract
Experimental and clinical evidence is presented which supports the hypothesis that CD8+ T lymphocytes aimed at suppressing HIV replication in infected CD4+ T cells may have an important role in the pathogenesis of AIDS by directly causing a decrease in CD4+ T lymphocyte numbers. Possible models to test this hypothesis are discussed.
摘要
本文提供了实验和临床证据，支持以下假说：旨在抑制受感染CD4+ T细胞中HIV复制的CD8+ T淋巴细胞，可能通过直接导致CD4+ T淋巴细胞数量减少，在艾滋病发病机制中发挥重要作用。文中还讨论了检验该假说的可能模型。
相似文献
1
A role for CD8+ T lymphocytes in the pathogenesis of AIDS.CD8 + T淋巴细胞在艾滋病发病机制中的作用。
Res Immunol. 1991 Sep;142(7):541-50. doi: 10.1016/0923-2494(91)90099-5.
2
Elevated levels of CD38+ CD8+ T cells in HIV infection add to the prognostic value of low CD4+ T cell levels: results of 6 years of follow-up. The Los Angeles Center, Multicenter AIDS Cohort Study.HIV感染中CD38+ CD8+ T细胞水平升高增加了低CD4+ T细胞水平的预后价值：6年随访结果。洛杉矶中心，多中心艾滋病队列研究。
J Acquir Immune Defic Syndr (1988). 1993 Aug;6(8):904-12.
3
T activation marker evaluation in ARC patients treated with AZT. Comparison with CD4+ lymphocyte count in non-progressors and progressors towards AIDS.接受齐多夫定治疗的艾滋病相关综合征（ARC）患者的T激活标志物评估。与未进展者及进展为艾滋病患者的CD4 +淋巴细胞计数的比较。
Clin Exp Immunol. 1990 Aug;81(2):177-82. doi: 10.1111/j.1365-2249.1990.tb03314.x.
4
During HIV infection, CD4+ CD38+ T-cells are the predominant circulating CD4+ subset whose HLA-DR positivity increases with disease progression and whose V beta repertoire is similar to that of CD4+ CD38- T-cells.在HIV感染期间，CD4+ CD38+ T细胞是主要的循环CD4+亚群，其HLA-DR阳性率随疾病进展而增加，且其Vβ库与CD4+ CD38- T细胞的相似。
Clin Immunol Immunopathol. 1995 Oct;77(1):33-41. doi: 10.1016/0090-1229(95)90134-5.
5
CD8+ T lymphocytes of African green monkeys secrete an immunodeficiency virus-suppressing lymphokine.非洲绿猴的CD8 + T淋巴细胞分泌一种抑制免疫缺陷病毒的淋巴因子。
Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7207-11. doi: 10.1073/pnas.91.15.7207.
6
[T-lymphocyte immune in HIV-infected people and AIDS patients in China].[中国HIV感染者及艾滋病患者的T淋巴细胞免疫]
Zhonghua Yi Xue Za Zhi. 2002 Oct 25;82(20):1391-5.
7
Proliferative response of CD4+ and CD8+ T cell subsets from Hispanics with HIV+ and AIDS: the superantigen hypothesis.
J Acquir Immune Defic Syndr (1988). 1994 Feb;7(2):124-8.
8
Reduced naive and increased activated CD4 and CD8 cells in healthy adult Ethiopians compared with their Dutch counterparts.与荷兰健康成年人相比，埃塞俄比亚健康成年人的初始CD4和CD8细胞减少，活化的CD4和CD8细胞增加。
Clin Exp Immunol. 1999 Mar;115(3):443-50. doi: 10.1046/j.1365-2249.1999.00815.x.
9
Effects of primary HIV-1 infection on subsets of CD4+ and CD8+ T lymphocytes.原发性HIV-1感染对CD4+和CD8+ T淋巴细胞亚群的影响。
AIDS. 1995 Jun;9(6):561-6. doi: 10.1097/00002030-199506000-00005.
10
Comparative clonal analysis of human immunodeficiency virus type 1 (HIV-1)-specific CD4+ and CD8+ cytolytic T lymphocytes isolated from seronegative humans immunized with candidate HIV-1 vaccines.从接种候选HIV-1疫苗的血清阴性个体中分离出的HIV-1特异性CD4+和CD8+细胞毒性T淋巴细胞的比较克隆分析
J Exp Med. 1992 Dec 1;176(6):1531-42. doi: 10.1084/jem.176.6.1531.
引用本文的文献
1
A longitudinal magnetization transfer imaging evaluation of brain injury in a macaque model of neuroAIDS.猕猴神经艾滋病模型中脑损伤的纵向磁化传递成像评估
AIDS Res Hum Retroviruses. 2015 Mar;31(3):335-41. doi: 10.1089/aid.2014.0166. Epub 2014 Nov 6.
2
Quantitative MRI Measures in SIV-Infected Macaque Brains.感染猴免疫缺陷病毒（SIV）的猕猴大脑中的定量磁共振成像测量
J Clin Cell Immunol. 2013;Suppl 7. doi: 10.4172/2155-9899.S7-005.
3
2-Carboxyethylgermanium sesquioxide, a synthetic organogermanium compound, as an inducer of contrasuppressor T cells.二羧乙基锗倍半氧化物，一种合成有机锗化合物，作为抗抑制性T细胞的诱导剂。
Experientia. 1996 Feb 15;52(2):159-66. doi: 10.1007/BF01923363.
4
Interlaboratory variability of CD8 subset measurements by flow cytometry and its applications to multicenter clinical trials. NAID/NICHD Women and Infants Transmission Study Group.流式细胞术检测 CD8 亚群的实验室间变异性及其在多中心临床试验中的应用。国家儿童健康与人类发展研究所妇女与婴儿传播研究组。
Clin Diagn Lab Immunol. 1995 Jul;2(4):462-8. doi: 10.1128/cdli.2.4.462-468.1995.
本文引用的文献
1
Soluble suppressor factors in patients with acquired immune deficiency syndrome and its prodrome. Elaboration in vitro by T lymphocyte-adherent cell interactions.获得性免疫缺陷综合征患者及其前驱期患者的可溶性抑制因子。通过T淋巴细胞与黏附细胞相互作用在体外的阐述。
J Clin Invest. 1983 Dec;72(6):2072-81. doi: 10.1172/JCI111172.
2
Immunoregulatory lymphokines of T hybridomas from AIDS patients: constitutive and inducible suppressor factors.艾滋病患者T杂交瘤的免疫调节性淋巴因子：组成型和诱导型抑制因子。
Science. 1984 Jul 6;225(4657):66-9. doi: 10.1126/science.6328662.
3
4
Extensive variation of human immunodeficiency virus type-1 in vivo.人类免疫缺陷病毒1型在体内的广泛变异。
Nature. 1988 Aug 4;334(6181):440-4. doi: 10.1038/334440a0.
5
Heterophil-negative mononucleosis-like illnesses with atypical lymphocytosis in patients undergoing seroconversions to the human immunodeficiency virus.
Am J Clin Pathol. 1988 Aug;90(2):169-74. doi: 10.1093/ajcp/90.2.169.
6
Mysteries of HIV: challenges for therapy and prevention.艾滋病病毒之谜：治疗与预防面临的挑战
Nature. 1988 Jun 9;333(6173):519-22. doi: 10.1038/333519a0.
7
The human immunodeficiency virus: infectivity and mechanisms of pathogenesis.人类免疫缺陷病毒：传染性与发病机制
Science. 1988 Feb 5;239(4840):617-22. doi: 10.1126/science.3277274.
8
9
In vitro cellular tropism of human B-lymphotropic virus (human herpesvirus-6).人嗜B淋巴细胞病毒（人类疱疹病毒6型）的体外细胞嗜性
J Exp Med. 1988 May 1;167(5):1659-70. doi: 10.1084/jem.167.5.1659.
10
Effects of cyclosporin on T-cell subsets in human immunodeficiency virus disease.环孢素对人类免疫缺陷病毒病中T细胞亚群的影响。
Clin Immunol Immunopathol. 1988 May;47(2):181-98. doi: 10.1016/0090-1229(88)90071-2.
Zotero 插件