CD8 + T淋巴细胞在艾滋病发病机制中的作用。
A role for CD8+ T lymphocytes in the pathogenesis of AIDS.
作者信息
Aranda-Anzaldo A
机构信息
Laboratoire d'Immunobiologie, Faculté de Médecine, Paris V.
出版信息
Res Immunol. 1991 Sep;142(7):541-50. doi: 10.1016/0923-2494(91)90099-5.
Abstract
Experimental and clinical evidence is presented which supports the hypothesis that CD8+ T lymphocytes aimed at suppressing HIV replication in infected CD4+ T cells may have an important role in the pathogenesis of AIDS by directly causing a decrease in CD4+ T lymphocyte numbers. Possible models to test this hypothesis are discussed.
摘要
本文提供了实验和临床证据，支持以下假说：旨在抑制受感染CD4+ T细胞中HIV复制的CD8+ T淋巴细胞，可能通过直接导致CD4+ T淋巴细胞数量减少，在艾滋病发病机制中发挥重要作用。文中还讨论了检验该假说的可能模型。
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