Fauci A S
National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.
Science. 1988 Feb 5;239(4840):617-22. doi: 10.1126/science.3277274.
Infection with the human immunodeficiency virus (HIV) results in a profound immunosuppression due predominantly to a selective depletion of helper/inducer T lymphocytes that express the receptor for the virus (the CD4 molecule). HIV also has tropism for the brain leading to neuropsychiatric abnormalities. Besides inducing cell death, HIV can interfere with T4 cell function by various mechanisms. The monocyte serves as a reservoir for HIV and is relatively refractory to its cytopathic effects. HIV can exist in a latent or chronic form which can be converted to a productive infection by a variety of inductive signals.
感染人类免疫缺陷病毒（HIV）会导致严重的免疫抑制，这主要是由于选择性地消耗了表达该病毒受体（CD4分子）的辅助/诱导性T淋巴细胞。HIV还对大脑具有嗜性，可导致神经精神异常。除了诱导细胞死亡外，HIV还可通过多种机制干扰T4细胞功能。单核细胞是HIV的储存库，并且对其细胞病变效应相对具有抗性。HIV可以以潜伏或慢性形式存在，多种诱导信号可将其转化为增殖性感染。
