Papa Giovanni, Grandi Giorgio, Pascone Michele
Department of Plastic and Reconstructive Surgery, University of Trieste, Ospedale di Cattinara, Strada di Fiume 447, Trieste, Italy.
Pathol Res Pract. 2006;202(9):691-4. doi: 10.1016/j.prp.2006.01.016. Epub 2006 Jul 31.
The coexistence of two malignant skin tumors intermingling in the same histologic specimen is rare. We report a case of melanoma in a basal cell carcinoma collision tumor. The presence of two intermingled neoplasms was confirmed by immunohistochemistry, which showed strong positivity for S-100 and HMB-45. A review of the literature and a case analysis allow for some pathogenetic and prognostic considerations.
在同一组织学标本中两种恶性皮肤肿瘤混合存在的情况较为罕见。我们报告了一例基底细胞癌碰撞瘤合并黑色素瘤的病例。免疫组化证实了两种混合肿瘤的存在，其显示S-100和HMB-45呈强阳性。文献回顾和病例分析有助于进行一些发病机制和预后方面的思考。
