Pouryazdanparast Pedram, Yu Limin, Johnson Timothy, Fullen Douglas
Department of Pathology, University of Michigan, Ann Arbor, MI 48109-0602, USA.
Am J Dermatopathol. 2009 Jul;31(5):457-61. doi: 10.1097/DAD.0b013e318182c7dc.
The presence of two intermingled malignant components within the same cutaneous tumor is rare. Herein, we report a case of an exceedingly rare squamo-melanocytic tumor, favored to be a melanoma variant. Although the biologic behavior and prognostic significance of this tumor remain to be established, this unique case reaffirms the potential morphologic diversity of melanoma. We review the literature reporting similar neoplasms and discuss the potential histogenesis of this squamo-melanocytic tumor.
同一皮肤肿瘤内存在两种相互交织的恶性成分的情况较为罕见。在此,我们报告一例极其罕见的鳞状黑素细胞肿瘤病例,倾向于将其视为黑色素瘤的一种变体。尽管该肿瘤的生物学行为和预后意义仍有待确定,但这一独特病例再次证实了黑色素瘤潜在的形态学多样性。我们回顾了报道类似肿瘤的文献,并讨论了这种鳞状黑素细胞肿瘤的潜在组织发生学。