Braun-Falco Markus
Department of Dermatology, University Medical Center Freiburg, Freiburg, Germany.
J Cutan Pathol. 2007 Sep;34(9):731-5. doi: 10.1111/j.1600-0560.2006.00703.x.
The combination of malignant melanoma (MM) and basal cell carcinoma (BCC) within a single tumor is an unusual finding.
An 84-year-old white man with a pigmented tumor on the back showing a combination of MM and BCC.
A 1.5 x 1.5-cm irregular brown lesion on the back was clinically suggestive of MM. Histopathologically, the lesions turned out to be a combined tumor consisting of a superficial BCC and a regressive MM with a tumor thickness of 1.25 mm. The conglomerates of the BCC lay within the MM and were admixed with a high number of Melan-A-positive melanocytic cells.
By reviewing the low number of published cases, we found that a combined MM-BCC tumor exists in two variants: a collision type in which components of each cell type are clearly demarcated and an intermingled type in which both cell types grow intimately together. Although both types occur as a mere incidence, in particular, the intermingled type may be diagnostically challenging and the evaluation of its dignity may be questionable.
单个肿瘤内同时存在恶性黑色素瘤（MM）和基底细胞癌（BCC）是一种不常见的发现。
一名84岁白人男性，背部有一个色素沉着肿瘤，显示为MM和BCC的组合。
背部一个1.5×1.5厘米的不规则褐色病变，临床提示为MM。组织病理学检查显示，病变为一个由浅表BCC和退行性MM组成的联合肿瘤，肿瘤厚度为1.25毫米。BCC的团块位于MM内部，并与大量Melan - A阳性黑素细胞混合。
通过回顾已发表的少量病例，我们发现MM - BCC联合肿瘤存在两种变体：一种是碰撞型，其中每种细胞类型的成分清晰可辨；另一种是混合型，两种细胞类型紧密生长在一起。虽然两种类型都只是偶然发生，但特别是混合型在诊断上可能具有挑战性，其性质评估可能存在疑问。
