重复序列之间的联系。

Links between repeated sequences.

作者信息

Matsutani Sachiko

机构信息

Division of Microbiology, National Institute of Health Sciences, Setagaya-ku, Tokyo 158-8501, Japan.

出版信息

J Biomed Biotechnol. 2006;2006(1):13569. doi: 10.1155/JBB/2006/13569.

DOI:10.1155/JBB/2006/13569

PMID:16877810

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1510936/

Abstract

L1 and Alu elements are long and short interspersed retrotransposable elements (LINEs and SINEs) in humans, respectively. Proteins encoded in the autonomous L1 mediate retrotransposition of the nonautonomous Alu and cellular mRNAs. Alu is the only active SINE in the human genome and is derived from 7SL RNA of signal recognition particle. In the other eukaryotic genomes, various tRNA- and 5S rRNA-derived SINEs are found. Some of the tRNA- and 5S rRNA-derived SINEs have partner LINEs of which 3' sequences are similar to those of the SINEs. One of the tRNA-derived SINEs is shown to be mobilized by its partner LINE. Many copies of tRNA and 5S rRNA pseudogenes are present in the human genome. These pseudogenes may have been generated via the retrotransposition process using L1 proteins. Although there are no sequence similarities between L1 and Alu, L1 functionally links with Alu and even cellular genes, impacting on our genome shaping.

摘要

L1元件和Alu元件分别是人类中的长散在核元件（LINEs）和短散在核元件（SINEs）。自主型L1元件所编码的蛋白质介导非自主型Alu元件和细胞信使核糖核酸的逆转座作用。Alu是人类基因组中唯一活跃的SINE，它来源于信号识别颗粒的7SL RNA。在其他真核生物基因组中，发现了各种来源于转运核糖核酸（tRNA）和5S核糖体核糖核酸（rRNA）的SINE。一些来源于tRNA和5S rRNA的SINE具有伙伴LINE，其3'序列与SINE的序列相似。已证明一种来源于tRNA的SINE可被其伙伴LINE动员。人类基因组中存在许多tRNA和5S rRNA假基因拷贝。这些假基因可能是通过使用L1蛋白的逆转座过程产生的。尽管L1和Alu之间没有序列相似性，但L1在功能上与Alu甚至细胞基因相联系，影响着我们基因组的形成。