Bigazzi P E, Yoshida T, Ward P A, Cohen S
Am J Pathol. 1975 Jul;80(1):69-78.
Macrophage migration inhibitory (MIF-like) activity was demonstrated in the supernatant fluids from primary cultures of African green monkey kidney cells infected with simian virus 40 (SV 40) virus. Kidney cell cultures not infected by virus had no MIF activity. Supernatant fluids from continuous cultures of nontransformed and SV 40-transformed human fibroblasts contained MIF-like activity. Productive infection with SV 40 virus results in the production of a lymphokine-like factor, as previously observed in other virus-cell systems, involving mumps virus and Newcast,le disease virus. However, while infection with these paramyxoviruses causes the production of macrophage and neutrophil chemotactic agents as well as an MIF, SV 40 infection does not induce chemotactic factors. The results reported here, taken in conjunction with previous observations by ourselves and others, suggest that the production of lymphokine-like factors (cytokines) may represent a general biologic phenomenon, and that many, if not all, cell types, when appropriately stimulated, may be capable of such activity.
在感染了猿猴病毒40（SV 40）的非洲绿猴肾细胞原代培养物的上清液中，证实了巨噬细胞迁移抑制（类MIF）活性。未感染病毒的肾细胞培养物没有MIF活性。来自未转化和SV 40转化的人成纤维细胞连续培养物的上清液含有类MIF活性。正如先前在其他病毒 - 细胞系统（涉及腮腺炎病毒和新城疫病毒）中所观察到的那样，SV 40病毒的有效感染导致产生一种类淋巴因子的因子。然而，虽然感染这些副粘病毒会导致产生巨噬细胞和中性粒细胞趋化剂以及一种MIF，但SV 40感染不会诱导趋化因子。结合我们自己和其他人先前的观察结果来看，这里报道的结果表明，类淋巴因子（细胞因子）的产生可能代表一种普遍的生物学现象，并且许多（如果不是全部）细胞类型在受到适当刺激时可能具有这种活性。
