干扰素与感染猿猴病毒40的细胞中早期病毒特异性RNA的转录
Interferon and transcription of early virus-specific RNA in cells infected with simian virus 40.
作者信息
Oxman M N, Levin M J
出版信息
Proc Natl Acad Sci U S A. 1971 Feb;68(2):299-302. doi: 10.1073/pnas.68.2.299.
Abstract
Treatment with interferon reduced the content of early virus-specific RNA, as well as the content of an early viral protein (T antigen), in monkey cells acutely infected with simian virus 40 (SV40). This unexpected finding suggests either that the action of interferon involves inhibition of the transcription of early SV40 messenger RNA, or that the SV40 genome contains a "proto-early" gene whose product is required for the transcription of the remaining early genes.
摘要
用干扰素处理可降低被猴病毒40（SV40）急性感染的猴细胞中早期病毒特异性RNA的含量以及一种早期病毒蛋白（T抗原）的含量。这一意外发现表明，干扰素的作用要么涉及抑制SV40早期信使RNA的转录，要么表明SV40基因组包含一个“原早期”基因，其产物是其余早期基因转录所必需的。
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