Inoue Y, Geczy C L, Nelson D S, Nelson M
Immunology. 1983 Apr;48(4):713-22.
Supernatants from cultures of rat and guinea-pig tumour cells, guinea-pig fibroblasts and kidney cells, but not rat fibroblasts, inhibited the migration of peritoneal exudate macrophages in vitro. The inhibitory activity in tumour-cell supernatants differed from that of lymphokine in being heat stable (60 degrees, 3 hr) and dialysable, not inhibited by fucose and, in the case of guinea-pig line 1 tumour, not absorbed by an anti-lymphokine immunoabsorbent. Rat lymphokine and supernatants from four cultured rat tumours and, to a lesser extent, fibroblasts induced procoagulant activity in rat peritoneal exudate macrophages. The tumour procoagulant-inducing activity was heat stable and non-dialysable. Direct procoagulant activity was also found in rat lymphokine, fibroblast and tumour culture supernatants. This activity was partly or completely heat-labile but was non-dialysable.
大鼠和豚鼠肿瘤细胞、豚鼠成纤维细胞及肾细胞（而非大鼠成纤维细胞）培养物的上清液在体外可抑制腹腔渗出巨噬细胞的迁移。肿瘤细胞上清液中的抑制活性与淋巴因子不同，其具有热稳定性（60摄氏度，3小时）且可透析，不受岩藻糖抑制，对于豚鼠1号线肿瘤而言，不被抗淋巴因子免疫吸附剂吸附。大鼠淋巴因子、四种培养的大鼠肿瘤的上清液以及程度较轻的成纤维细胞可诱导大鼠腹腔渗出巨噬细胞产生促凝活性。肿瘤促凝诱导活性具有热稳定性且不可透析。在大鼠淋巴因子、成纤维细胞及肿瘤培养上清液中也发现了直接促凝活性。这种活性部分或完全不耐热，但不可透析。
