吸烟者的外周微循环严重紊乱。

Smokers have severely disturbed peripheral micro-circulation.

作者信息

Midttun M, Sejrsen P, Paaske W P

机构信息

Department of Geriatrics, Bispebjerg Hospital, Copenhagen, Denmark.

出版信息

Int Angiol. 2006 Sep;25(3):293-6.

PMID:16878079

Abstract

AIM

The aim of this study was to determine the effect of smoking a single cigarette on the blood flow rates in capillaries and arteriovenous anastomoses (AVAs) in light and heavy smokers in: a) the skin fold between the first and second fingers, and b) the pulp of the thumb.

METHODS

Five light (10-12 cigarettes/day) and 5 heavy (>20 cigarettes/day) chronic smokers participated (4 men and 6 women, median age 40.5 years). The blood flow rates were measured by the (133)Xenon local washout method (capillaries, skin fold) and the heat washout method (AVAs, thumb pulp), respectively, before, during, and after smoking of a single Prince cigarette (0.9 mg nicotine).

RESULTS

The blood flow rate (f) in mL(100 g(min)(-1) [standard error, SE] in skin capillaries of light smokers was 24.4 [9], 8.9 [1.8], and 10.4 [3.3] before, during, and after smoking of one cigarette; in heavy smokers, f was 23.6 [10.9], 16.1 [5.3], and 7.1 [2.9]; f in pulp AVAs of light smokers was 130.6 [14.9], 49.2 [24.8], and 119.7 [20.9] before, during, and after smoking; in heavy smokers, the corresponding results were 134.4 [19.1], 136.2 [13.5], and 143 [15.3]. Thus, the blood flow rate in capillaries of both light and heavy smokers was higher before smoking the test cigarette than previously observed in non-smokers. In light smokers blood flow rate in AVAs decreased during smoking with a factor of 2.6, and it returned to the pre-smoking level immediately after the end of smoking the cigarette. In heavy smokers, f remained unchanged before, during, and after smoking.

CONCLUSIONS

Smokers have severely disturbed peripheral microcirculation.

摘要

目的

本研究旨在确定吸一支香烟对轻度和重度吸烟者以下部位毛细血管及动静脉吻合支（AVA）血流速度的影响：a）食指和中指间的皮肤褶皱处；b）拇指指腹。

方法

招募了5名轻度（每日吸10 - 12支烟）和5名重度（每日吸＞20支烟）慢性吸烟者（4名男性和6名女性，年龄中位数40.5岁）。分别采用（133）氙局部洗脱法（用于测量毛细血管，皮肤褶皱处）和热洗脱法（用于测量AVA，拇指指腹），在吸一支Prince牌香烟（含0.9毫克尼古丁）之前、期间和之后测量血流速度。

结果

轻度吸烟者皮肤毛细血管的血流速度（f，单位为mL(100 g(min)(-1) [标准误差，SE]）在吸一支烟之前、期间和之后分别为24.4 [9]、8.9 [1.8]和10.4 [3.3]；重度吸烟者分别为23.6 [10.9]、16.1 [5.3]和7.1 [2.9]；轻度吸烟者指腹AVA的血流速度在吸一支烟之前、期间和之后分别为130.6 [14.9]、49.2 [24.8]和119.7 [20.9]；重度吸烟者相应结果分别为134.4 [19.1]、136.2 [13.5]和143 [15.3]。因此，轻度和重度吸烟者在吸测试香烟之前，其毛细血管中的血流速度均高于之前在非吸烟者中观察到的水平。在轻度吸烟者中，AVA的血流速度在吸烟期间下降了2.6倍，并在吸烟结束后立即恢复到吸烟前水平。在重度吸烟者中，f在吸烟之前、期间和之后保持不变。