Krasse Per, Carlsson Birgitta, Dahl Carina, Paulsson Annette, Nilsson Asa, Sinkiewicz Gabriela
Malmö University, Dept Biomedical Lab Sciences, Sweden.
Swed Dent J. 2006;30(2):55-60.
The primary aim of this study was to assess if the probiotic Lactobacillus reuteri could be effective in the treatment of gingivitis and further to evaluate the influence of the probiotic on plaque and the lactobacilli population in the saliva. A randomised, placebo-controlled, double blind study was performed over 2 weeks. Fifty-nine patients with moderate to severe gingivitis were included and given one of two different Lactobacillus reuteri formulations (LR-1 or LR-2) at a dose of 2 x 10(8) CFU per day, or a corresponding placebo. At baseline (day 0) gingival index and plaque index were measured on two surfaces and saliva for lactobacilli determination was collected. The patients were instructed how to brush and floss efficiently and study treatment was started.The patients returned on day 14 for final assessment of gingivitis and plaque and saliva was collected. 20 patients were randomised to LR-1, 21 to LR-2 and 18 to placebo. Gingival index fell significantly in all 3 groups (p < 0.0001). LR-1, but not LR-2 improved more than placebo (p < 0.0001). Plaque index fell significantly in LR-1 (p < 0.05) and in LR-2 (p < 0.01) between day o and day 14 but there was no significant change in the placebo group. At day 14, 65% of the patients in LR-1 were colonised with Lactobacillus reuteri and 95% in the LR-2 group. Lactobacillus reuteri was efficacious in reducing both gingivitis and plaque in patients with moderate to severe gingivitis.
本研究的主要目的是评估益生菌罗伊氏乳杆菌是否对牙龈炎治疗有效，并进一步评估该益生菌对菌斑和唾液中乳杆菌菌群的影响。进行了一项为期2周的随机、安慰剂对照、双盲研究。纳入了59例中重度牙龈炎患者，给予两种不同的罗伊氏乳杆菌制剂（LR-1或LR-2）之一，剂量为每天2×10⁸CFU，或相应的安慰剂。在基线（第0天）时，测量两个牙面的牙龈指数和菌斑指数，并收集唾液用于测定乳杆菌。指导患者如何有效地刷牙和使用牙线，然后开始研究治疗。患者在第14天返回进行牙龈炎和菌斑的最终评估，并收集唾液。20例患者被随机分配至LR-1组，21例至LR-2组，18例至安慰剂组。所有3组的牙龈指数均显著下降（p<0.0001）。LR-1组改善程度超过安慰剂组（p<0.0001），而LR-2组未超过。在第0天至第14天期间，LR-1组（p<0.05）和LR-2组（p<0.01）的菌斑指数显著下降，但安慰剂组无显著变化。在第14天，LR-1组65%的患者口腔中定植了罗伊氏乳杆菌，LR-2组为95%。罗伊氏乳杆菌对减轻中重度牙龈炎患者的牙龈炎和菌斑均有效。
