Ventura M T, Polimeno L, Amoruso A C, Gatti F, Annoscia E, Marinaro M, Di Leo E, Matino M G, Buquicchio R, Bonini S, Tursi A, Francavilla A
Department of Internal Medicine, Immunology and Infectious Diseases (MIDIM), University of Bari Medical School, Policlinico, Piazza G. Cesare n 11, 70124 Bari, Italy.
Dig Liver Dis. 2006 Oct;38(10):732-6. doi: 10.1016/j.dld.2006.06.012. Epub 2006 Jul 31.
An abnormal intestinal permeability could contribute to establish an altered sensitivity to food-allergen.
To evaluate the intestinal permeability in subjects with adverse reactions to food on allergen-free diet.
Twenty-one patients with food allergy and 20 with food hypersensitivity on allergen-free diet were enrolled and divided in four groups according to the seriousness of their referred clinical symptoms when they were on a free diet.
Intestinal permeability was evaluated by Lactulose/Mannitol ratio urinary detection determined by anion-exchange chromatography.
Statistically significant different Lactulose/Mannitol ratio was evidenced in subjects with food allergy (p=0.003) or hypersensitivity (p=0.0008) compared to control patients. The correlation between Lactulose/Mannitol ratio and the seriousness of clinical symptoms, by using Spearman test, was statistically significant for food allergy (p=0.0195) and hypersensitivity (p=0.005) patients.
The present data demonstrate that impaired intestinal permeability, measured in our conditions, is present in all subjects with adverse reactions to food. In addition, for the first time, we report a statistically significant association between the severity of referred clinical symptoms and the increasing of Intestinal Permeability Index. These data reveal that intestinal permeability is not strictly dependent on IgE-mediated processes but could better be related to other mechanisms involved in early food sensitisation, as breast-feeding, or microbial environment that influence the development of oral tolerance in early infancy.
肠道通透性异常可能导致对食物过敏原的敏感性改变。
评估在无过敏原饮食条件下对食物有不良反应的受试者的肠道通透性。
招募了21名食物过敏患者和20名在无过敏原饮食条件下食物过敏的患者，并根据他们在无过敏原饮食时所报告临床症状的严重程度分为四组。
通过阴离子交换色谱法测定尿乳果糖/甘露醇比值来评估肠道通透性。
与对照患者相比，食物过敏（p = 0.003）或过敏（p = 0.0008）患者的乳果糖/甘露醇比值有统计学显著差异。使用Spearman检验，食物过敏（p = 0.0195）和过敏（p = 0.005）患者的乳果糖/甘露醇比值与临床症状严重程度之间的相关性具有统计学意义。
目前的数据表明，在我们的条件下测量的肠道通透性受损存在于所有对食物有不良反应的受试者中。此外，我们首次报告了所报告临床症状的严重程度与肠道通透性指数增加之间存在统计学显著关联。这些数据表明，肠道通透性并不严格依赖于IgE介导的过程，而可能更好地与早期食物致敏中涉及的其他机制相关，如母乳喂养或影响婴儿早期口服耐受发展的微生物环境。
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