Wang Hao, Wu Fei-Hua, Xiong Fei, Wu Jia-Jun, Zhang Lu-Yong, Ye Wen-Cai, Li Ping, Zhao Shou-Xun
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, P.R. China.
Chem Pharm Bull (Tokyo). 2006 Aug;54(8):1144-9. doi: 10.1248/cpb.54.1144.
Four new non-glycosidic iridoids, piscrocins D (1), E (2), F (6), and G (7), as well as two new iridoid glycosides, piscrosides A (8) and B (9), were isolated from the roots of Neopicrorhiza scrophulariiflora (Scrophulariaceae), together with seven known iridoids. The structures of the isolated compounds were established by means of 1D and 2D NMR spectroscopy and chemical methods. The hepatoprotective activities of these compounds were evaluated by measuring their effects on CCl(4)-induced hepatocytes damage in vitro, and the structure-activity relationships were also discussed.
从玄参科植物新藏玄参（Neopicrorhiza scrophulariiflora）的根中分离得到4个新的非糖苷类环烯醚萜，即獐牙菜苦素D（1）、E（2）、F（6）和G（7），以及2个新的环烯醚萜苷，即獐牙菜苷A（8）和B（9），同时还得到7个已知的环烯醚萜。通过一维和二维核磁共振光谱以及化学方法确定了分离得到的化合物的结构。通过测定这些化合物对四氯化碳诱导的体外肝细胞损伤的影响来评估其保肝活性，并对构效关系进行了讨论。
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