来自石仙桃的二苯乙烯衍生物及其抗炎活性。
Stilbene derivatives from Pholidota chinensis and their anti-inflammatory activity.
作者信息
Wang Jue, Matsuzaki Keiichi, Kitanaka Susumu
机构信息
Department of Pharmacognosy, College of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, China.
出版信息
Chem Pharm Bull (Tokyo). 2006 Aug;54(8):1216-8. doi: 10.1248/cpb.54.1216.
Ethyl acetate extract of Pholidota chinensis L. showed strong NO production inhibitory activity in murine macrophage-like cell line, RAW 264.7, which was activated by a lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma). Fractionation of the active extract led to the isolation of two new stilbene derivatives, 2,3'-dihydroxy-5-methoxy-3,4-methylenedioxydihydrostilbene (Pholidotol A) and 2-hydroxy-5-methoxy-3,4,3',4'-dimethylenedioxydihydrostilbene (Pholidotol B) together with six known stilbene derivatives. Pholidotols A both B and inhibited Nitric oxide (NO) production with an IC(50) value at 24.3 and 17.1 microM, respectively.
石仙桃乙酸乙酯提取物在经脂多糖（LPS）和γ-干扰素（IFN-γ）激活的小鼠巨噬细胞样细胞系RAW 264.7中表现出很强的一氧化氮生成抑制活性。对活性提取物进行分离，得到两种新的芪衍生物，2,3'-二羟基-5-甲氧基-3,4-亚甲基二氧基二氢芪（石仙桃醇A）和2-羟基-5-甲氧基-3,4,3',4'-二亚甲基二氧基二氢芪（石仙桃醇B），以及六种已知的芪衍生物。石仙桃醇A和B均抑制一氧化氮（NO）生成，IC50值分别为24.3和17.1微摩尔。
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