胨假说与自身免疫 - Suppr

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The pepton hypothesis and autoimmunity.

作者信息

Mackay I R, Rowley M, Loveland B, Marzuki S

机构信息

Centre for Molecular Biology and Medicine, Monash University, Clayton, Victoria, Australia.

出版信息

Immunogenetics. 1990;31(1):61-2. doi: 10.1007/BF00702491.

DOI:10.1007/BF00702491

PMID:1688824

Abstract

摘要

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The pepton hypothesis and autoimmunity.胨假说与自身免疫

Immunogenetics. 1990;31(1):61-2. doi: 10.1007/BF00702491.

Mitochondrial pyruvate dehydrogenase complex subunits as autoantigens in human primary biliary cirrhosis.线粒体丙酮酸脱氢酶复合体亚基作为人类原发性胆汁性肝硬化中的自身抗原

Biochem Int. 1991 Feb;23(3):429-37.

Differing epitope selection of experimentally-induced and natural antibodies to a disease-specific autoantigen, the E2 subunit of pyruvate dehydrogenase complex (PDC-E2).针对疾病特异性自身抗原——丙酮酸脱氢酶复合体（PDC-E2）的E2亚基，实验诱导抗体和天然抗体的表位选择存在差异。

Int Immunol. 1992 Nov;4(11):1245-53. doi: 10.1093/intimm/4.11.1245.

What makes an autoantigen an autoantigen?自身抗原为何成为自身抗原？

Ann N Y Acad Sci. 2005 Jun;1050:134-45. doi: 10.1196/annals.1313.015.

The pyruvate dehydrogenase complex as a target autoantigen in primary biliary cirrhosis.丙酮酸脱氢酶复合体作为原发性胆汁性肝硬化中的靶自身抗原。

Baillieres Best Pract Res Clin Gastroenterol. 2000 Aug;14(4):535-47. doi: 10.1053/bega.2000.0102.

HLA DRB4 0101-restricted immunodominant T cell autoepitope of pyruvate dehydrogenase complex in primary biliary cirrhosis: evidence of molecular mimicry in human autoimmune diseases.原发性胆汁性肝硬化中丙酮酸脱氢酶复合体的HLA DRB4 0101限制性免疫显性T细胞自身表位：人类自身免疫性疾病中分子模拟的证据

J Exp Med. 1995 May 1;181(5):1835-45. doi: 10.1084/jem.181.5.1835.

Human monoclonal antibodies from a patient with primary biliary cirrhosis that recognize two distinct autoepitopes in the E2 component of the pyruvate dehydrogenase complex.来自一名原发性胆汁性肝硬化患者的人单克隆抗体，可识别丙酮酸脱氢酶复合体E2成分中的两个不同自身表位。

Hepatology. 1993 Nov;18(5):1069-77.

T cell responses to natural human proteins in primary biliary cirrhosis.原发性胆汁性肝硬化中T细胞对天然人类蛋白质的反应。

Clin Exp Immunol. 1997 Mar;107(3):562-8. doi: 10.1046/j.1365-2249.1997.3101202.x.

Primary biliary cirrhosis: for want of an X chromosome?原发性胆汁性肝硬化：因缺少一条X染色体所致？

Lancet. 2004 Feb 14;363(9408):505-6. doi: 10.1016/S0140-6736(04)15576-1.

Multiple autoepitope presentation for specific detection of antibodies in primary biliary cirrhosis.用于原发性胆汁性肝硬化中抗体特异性检测的多重自身表位呈递

Hepatology. 1992 Dec;16(6):1395-403. doi: 10.1002/hep.1840160615.

引用本文的文献

Do we need a pepton hypothesis?

Immunogenetics. 1991;34(1):1-4. doi: 10.1007/BF00212305.

本文引用的文献

Autoantibodies are anti-idiotype antibodies to antiviral antibodies.自身抗体是针对抗病毒抗体的抗独特型抗体。

Lancet. 1983 Oct 8;2(8354):824-6. doi: 10.1016/s0140-6736(83)90740-7.

Molecular mimicry and autoimmune disease.分子模拟与自身免疫性疾病。

Cell. 1987 Sep 11;50(6):819-20. doi: 10.1016/0092-8674(87)90507-1.

Identification and specificity of a cDNA encoding the 70 kd mitochondrial antigen recognized in primary biliary cirrhosis.原发性胆汁性肝硬化中识别的编码70kd线粒体抗原的cDNA的鉴定及特异性

J Immunol. 1987 May 15;138(10):3525-31.

Mta, the maternally transmitted antigen, is determined jointly by the chromosomal Hmt and the extrachromosomal Mtf genes.母系传播抗原Mta由染色体Hmt基因和染色体外Mtf基因共同决定。

J Exp Med. 1986 Feb 1;163(2):334-46. doi: 10.1084/jem.163.2.334.

T cell-recognized antigenic peptides derived from the cellular genome are not protein degradation products but can be generated directly by transcription and translation of short subgenic regions. A hypothesis.源自细胞基因组的T细胞识别抗原肽并非蛋白质降解产物，而是可由短亚基因区域直接转录和翻译产生。一种假说。

Immunogenetics. 1989;29(2):75-9. doi: 10.1007/BF00395854.

Nature of the mitochondrial antigens of primary biliary cirrhosis and their possible relationships to the etiology of the disease.

Semin Liver Dis. 1989 May;9(2):117-23. doi: 10.1055/s-2008-1040502.

Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology.抗核抗体：自身免疫性疾病的诊断标志物及细胞生物学探针

Adv Immunol. 1989;44:93-151. doi: 10.1016/s0065-2776(08)60641-0.

Immunologic tolerance: collaboration between antigen and lymphokines.免疫耐受：抗原与淋巴因子之间的协同作用。

Science. 1989 Jul 14;245(4914):147-53. doi: 10.1126/science.2526369.

Molecular basis of mitochondrial autoreactivity in primary biliary cirrhosis.

Immunol Today. 1989 Sep;10(9):315-8. doi: 10.1016/0167-5699(89)90088-1.

Characterisation of the reactivity of autoantibodies in primary biliary cirrhosis.原发性胆汁性肝硬化中自身抗体反应性的特征分析

FEBS Lett. 1989 Mar 27;246(1-2):49-53. doi: 10.1016/0014-5793(89)80251-0.

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