Lindahl K F, Hausmann B, Robinson P J, Guénet J L, Wharton D C, Winking H
J Exp Med. 1986 Feb 1;163(2):334-46. doi: 10.1084/jem.163.2.334.
Mus spretus from four stocks, originating in Spain, Portugal, and Morocco, were tested for the maternally transmitted antigen, Mta. All expressed a variant form not found in other species of mice. Analysis of appropriate crosses with inbred mice showed that the spretus form of Mta is determined by a new allele, c, of the Hmt gene. The Hmtc allele has been isolated in coupling with four different H-2 haplotypes. It is possible to raise CTL specific for the spretus form of Mta. The maternally transmitted factor, Mtf alpha s, of spretus mice determines, in conjunction with the Hmta allele of C57BL/6, an Mta that is indistinguishable from the common form found in C57BL/6 and most other inbred mice. Our experiments show that the specificity of the cell surface antigen Mta is governed jointly by the cytoplasmic gene Mtf and the chromosomal gene Hmt. We propose that Hmt encodes a class I histocompatibility antigen that acts as a restricting element for the Mtf gene product, thus meeting the requirements of T killer cell recognition.
对源自西班牙、葡萄牙和摩洛哥的四个种群的小家鼠进行了母系传播抗原Mta的检测。所有小家鼠都表达了一种在其他小鼠物种中未发现的变体形式。与近交系小鼠进行适当杂交的分析表明，小家鼠的Mta形式由Hmt基因的一个新等位基因c决定。Hmtc等位基因已与四种不同的H-2单倍型连锁分离。有可能产生针对小家鼠形式Mta的特异性CTL。小家鼠的母系传播因子Mtfαs与C57BL/6的Hmta等位基因共同决定了一种与C57BL/6和大多数其他近交系小鼠中发现的常见形式无法区分的Mta。我们的实验表明，细胞表面抗原Mta的特异性由细胞质基因Mtf和染色体基因Hmt共同控制。我们提出，Hmt编码一种I类组织相容性抗原，作为Mtf基因产物的限制元件，从而满足T杀伤细胞识别的要求。
