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4.5S RNA 的缺失会诱导大肠杆菌中的热休克反应和λ原噬菌体。

Loss of 4.5S RNA induces the heat shock response and lambda prophage in Escherichia coli.

作者信息

Bourgaize D B, Phillips T A, VanBogelen R A, Jones P G, Neidhardt F C, Fournier M J

机构信息

Department of Biochemistry, University of Massachusetts, Amherst 01003.

出版信息

J Bacteriol. 1990 Feb;172(2):1151-4. doi: 10.1128/jb.172.2.1151-1154.1990.

DOI:10.1128/jb.172.2.1151-1154.1990
PMID:1688840
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC208552/
Abstract

During depletion of 4.5S RNA, cells of Escherichia coli displayed a heat shock response that was simultaneous with the first detectable effect on ribosome function and before major effects on cell growth. Either 4.5S RNA is involved directly in regulating the heat shock response, or this particular impairment of protein synthesis uniquely induces the heat shock response. Several hours later, lambda prophage was induced and the cells lysed.

摘要

在4.5S RNA耗竭期间，大肠杆菌细胞表现出热休克反应，这与对核糖体功能的首次可检测到的影响同时发生，且在对细胞生长产生重大影响之前。要么4.5S RNA直接参与调节热休克反应，要么这种蛋白质合成的特定损伤独特地诱导了热休克反应。几小时后，λ原噬菌体被诱导，细胞裂解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4be4/208552/4d982d78ff77/jbacter01044-0650-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4be4/208552/4d982d78ff77/jbacter01044-0650-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4be4/208552/4d982d78ff77/jbacter01044-0650-a.jpg

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