Rauter Harald, Barral Yves
Institute of Biochemistry, Eidgenössische Technische Hochschule Zurich, 8093 Zurich, Switzerland.
Dev Cell. 2006 Aug;11(2):136-7. doi: 10.1016/j.devcel.2006.07.010.
Temporal and spatial coordination of cytokinesis with chromosome segregation is key for successful cell division, but it is poorly understood. A recent article in Science by Pellman and coworkers (Yoshida et. al., 2006) reveals how the yeast polo-like kinase Cdc5 triggers Rho1/RhoA activation and the assembly of the contractile actin ring during anaphase.
胞质分裂与染色体分离的时空协调是细胞成功分裂的关键,但目前对此了解甚少。佩尔曼及其同事近期发表在《科学》杂志上的一篇文章(吉田等人,2006年)揭示了酵母中类polo激酶Cdc5在后期如何触发Rho1/RhoA激活以及收缩性肌动蛋白环的组装。