Syrenicz Anhelli, Garanty-Bogacka Barbara, Syrenicz Małgorzata, Gebala Aneta, Dawid Grazyna, Walczak Mieczysław
Department of Endocrinology, Arterial Hypertension and Metabolic Diseases, Pomeranian Medical University, Szczecin, Poland.
Neuro Endocrinol Lett. 2006 Aug;27(4):459-64.
To determine the role of low-grade, systemic inflammation and endothelial activation in the modulation of blood pressure (BP) independently of other traditional risk factors in obese children and adolescents.
We surveyed 281 obese subjects, aged 6-18 years to investigate the relationship of serum inflammation and endothelial activation markers and blood pressure.
Clinical variables, indices of obesity, ambulatory 24-h blood pressure and serum concentrations of C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta), intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), glucose and insulin. HOMA IR was used as a marker of insulin resistance (IR).
CRP, IL-6, IL-1 beta, and ICAM-1 correlated significantly with mean 24-h systolic BP, whereas CRP and IL-6 was positively correlated with mean 24-h diastolic BP. Multiple regression analysis showed that serum IL-6 (P < .001) concentration, HOMA IR (P < .01), and waist to hip ratio (P < .05) were the significant determinants of systolic BP, whereas CRP (P < .05) level was the only predictor of diastolic BP. There were no significant associations of cell adhesion molecules with BP.
These results indicate that low-grade inflammation may play a role in the modulation of arterial BP relatively early in life.
确定低度全身性炎症和内皮激活在肥胖儿童及青少年血压（BP）调节中的作用，且独立于其他传统危险因素。
我们对281名6至18岁的肥胖受试者进行了调查，以研究血清炎症和内皮激活标志物与血压之间的关系。
临床变量、肥胖指数、24小时动态血压以及血清中C反应蛋白（CRP）、白细胞介素-6（IL-6）、白细胞介素-1β（IL-1β）、细胞间黏附分子-1（ICAM-1）、血管细胞黏附分子-1（VCAM-1）、葡萄糖和胰岛素的浓度。采用稳态模型评估胰岛素抵抗（HOMA IR）作为胰岛素抵抗（IR）的标志物。
CRP、IL-6、IL-1β和ICAM-1与24小时平均收缩压显著相关，而CRP和IL-6与24小时平均舒张压呈正相关。多元回归分析显示，血清IL-6浓度（P <.001）、HOMA IR（P <.01）和腰臀比（P <.05）是收缩压的显著决定因素，而CRP水平（P <.05）是舒张压的唯一预测因子。细胞黏附分子与血压无显著关联。
这些结果表明，低度炎症可能在生命早期对动脉血压的调节中发挥作用。
