Awan M A, Tarin S A
Wolverhampton Eye Infirmary, Wolverhampton, UK.
Surgeon. 2006 Aug;4(4):231-6. doi: 10.1016/s1479-666x(06)80065-x.
Photodynamic Therapy (PDT) is an emerging treatment for a variety of conditions including ocular and extra ocular diseases. The porphyrins have been used extensively, as dyes, which are laser-activated to achieve desired clinical effects. Commonly used agents are verteporfin and porfimer sodium.
We performed a literature search of the PubMed database using the medical search headings: photodynamic therapy, photosensitizer verteporfin, visudyne, porfimer sodium and photofrin. We also performed a manual search using references from these articles, review articles and manufacturers' product monographs.
Verteporfin and porfimer sodium are commonly used photosensitizing agents with their wide applications in different fields of medicine. Both have well established safety profiles. They are most commonly used in wet age-related macular degeneration, gastrointestinal diseases and bronchial cancers.
PDT is a well established treatment entity in ophthalmology and other medical fields. In ophthalmology, it has rekindled interest and hopes in the common yet sight-threatening problem of age-related macular degeneration (AMD). This problem is still considered to be a serious issue as far as management is concerned. However in selective cases of AMD, it has shown success in restoring sight, especially in the 'classic' form of the disease. PDT is also being used to treat a range of solid cancers and non malignant conditions
光动力疗法（PDT）是一种新兴的治疗方法，可用于治疗包括眼科和眼外疾病在内的多种病症。卟啉作为染料已被广泛使用，其通过激光激活以达到预期的临床效果。常用的药物是维替泊芬和卟吩姆钠。
我们使用医学检索词“光动力疗法”“光敏剂维替泊芬”“维速达尔”“卟吩姆钠”和“光卟啉”在PubMed数据库中进行文献检索。我们还使用这些文章的参考文献、综述文章和制造商的产品说明书进行了人工检索。
维替泊芬和卟吩姆钠是常用的光敏剂，在医学的不同领域有着广泛应用。两者都有公认的安全性。它们最常用于湿性年龄相关性黄斑变性、胃肠道疾病和支气管癌。
光动力疗法在眼科和其他医学领域是一种成熟的治疗方法。在眼科领域，它重新点燃了人们对常见但威胁视力的年龄相关性黄斑变性（AMD）问题的兴趣和希望。就治疗而言，这个问题仍然被认为是一个严重的问题。然而，在AMD的某些特定病例中，它已成功恢复视力，尤其是在该疾病的“典型”形式中。光动力疗法也正被用于治疗一系列实体癌和非恶性病症
