Rogers Jason L, Kesner Raymond P
Department of Psychology, University of Utah, Salt Lake City, UT 84112, USA.
Behav Neurosci. 2006 Aug;120(4):852-60. doi: 10.1037/0735-7044.120.4.852.
The present experiments used 2 versions of a modified Hebb-Williams maze to test the role of the dorsal hippocampus (dHip) and parietal cortex (PC) in processing allocentric and egocentric space during acquisition and retention. Bilateral lesions were made to either the dHip or PC before maze testing (acquisition) or after maze testing (retention). The results indicate that lesions of the dHip impair allocentric maze acquisition, whereas lesions of the PC impair egocentric maze acquisition. During retention, lesions of the PC produced a significant impairment on both maze versions, whereas lesions of the dHip produced short-lived, transient impairments on both maze versions. These results suggest that during acquisition, the hippocampus and PC process spatial information in parallel; however, long-term retention of spatial information requires the PC with the dHIP as necessary for retrieval and/or access but not necessarily storage.
本实验使用了两种改良版的赫布-威廉姆斯迷宫，以测试背侧海马体（dHip）和顶叶皮质（PC）在习得和记忆过程中处理空间方位和自我中心空间方面的作用。在迷宫测试（习得）之前或之后，对dHip或PC进行双侧损伤。结果表明，dHip损伤会损害空间方位迷宫的习得，而PC损伤则会损害自我中心迷宫的习得。在记忆阶段，PC损伤对两种迷宫版本均产生了显著损害，而dHip损伤对两种迷宫版本都产生了短暂的、临时性的损害。这些结果表明，在习得过程中，海马体和PC并行处理空间信息；然而，空间信息的长期记忆需要PC与dHIP协同作用，以便进行检索和/或获取，但不一定用于存储。
