Shimamoto Kazuaki, Ura Nobuyuki
The Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
Clin Exp Hypertens. 2006 Aug;28(6):543-52. doi: 10.1080/10641960600851900.
Insulin resistance and hyperinsulinemia are common findings in patients with essential hypertension. Recent evidence indicates that these impairments in glucose metabolism may play a role not only in the development of type 2 diabetes, but also in the onset and persistence of hypertension, dyslipidemia, and abdominal obesity. The accumulation of these risk factors constitutes a high-risk group of cardiovascular diseases, the so-called metabolic syndrome. Insulin resistance has also been reported in several animal models for hypertension, including the spontaneously hypertensive rat (SHR) and the fructose-fed rat (FFR). SHRs and FFRs have been employed in many studies to investigate the mechanisms and pathophysiology of insulin resistance and hypertension, but the precise mechanism of insulin resistance remains to be clarified. In this review, the possible mechanisms of insulin resistance in SHRs and FFRs are summarized.
胰岛素抵抗和高胰岛素血症在原发性高血压患者中很常见。最近的证据表明，这些糖代谢障碍不仅可能在2型糖尿病的发生中起作用，而且在高血压、血脂异常和腹型肥胖的发生及持续存在中也起作用。这些危险因素的聚集构成了心血管疾病的高危人群，即所谓的代谢综合征。在几种高血压动物模型中也报道了胰岛素抵抗，包括自发性高血压大鼠（SHR）和喂食果糖的大鼠（FFR）。SHR和FFR已被用于许多研究，以探讨胰岛素抵抗和高血压的机制及病理生理学，但胰岛素抵抗的确切机制仍有待阐明。在这篇综述中，总结了SHR和FFR中胰岛素抵抗的可能机制。
