Milder Ivon E J, Feskens Edith J M, Arts Ilja C W, Bueno-de-Mesquita H Bas, Hollman Peter C H, Kromhout Daan
Centre for Nutrition and Health, National Institute for Public Health and the Environment, Bilthoven, Netherlands.
Am J Clin Nutr. 2006 Aug;84(2):400-5. doi: 10.1093/ajcn/84.1.400.
Plant lignans are converted to enterolignans that have antioxidant and weak estrogen-like activities, and therefore they may lower cardiovascular disease and cancer risks.
We investigated whether the intakes of 4 plant lignans (lariciresinol, pinoresinol, secoisolariciresinol, and matairesinol) were inversely associated with coronary heart disease (CHD), cardiovascular diseases (CVD), cancer, and all-cause mortality.
The Zutphen Elderly Study is a prospective cohort study in which 570 men aged 64-84 y were followed for 15 y. We recently developed a database and used it to estimate the dietary intakes of 4 plant lignans. Lignan intake was related to mortality with the use of Cox proportional hazards analysis.
The median total lignan intake in 1985 was 977 microg/d. Tea, vegetables, bread, coffee, fruit, and wine were the major sources of lignan. The total lignan intake was not related to mortality. However, the intake of matairesinol was inversely associated with CHD, CVD, and all-cause mortality (P </= 0.05 for all) and cancer (P = 0.06). Multivariate-adjusted rate ratios (95% CI) per 1-SD increase in intake were 0.72 (0.53, 0.98) for CHD, 0.83 (0.69, 1.00) for CVD, 0.86 (0.76, 0.97) for all-cause mortality, and 0.81 (0.65, 1.00) for cancer.
Total lignan intake was not associated with mortality. The intake of matairesinol was inversely associated with mortality due to CHD, CVD, cancer, and all causes. We cannot exclude the possibility that the inverse association between matairesinol intake and mortality is due to an associated factor, such as wine consumption.
植物木脂素可转化为具有抗氧化和弱雌激素样活性的肠内木脂素，因此它们可能降低心血管疾病和癌症风险。
我们调查了4种植物木脂素（落叶松脂醇、松脂醇、开环异落叶松脂醇和罗汉松脂醇）的摄入量是否与冠心病（CHD）、心血管疾病（CVD）、癌症及全因死亡率呈负相关。
祖特芬老年研究是一项前瞻性队列研究，对570名年龄在64 - 84岁的男性进行了15年的随访。我们最近建立了一个数据库，并使用它来估计4种植物木脂素的膳食摄入量。使用Cox比例风险分析评估木脂素摄入量与死亡率的关系。
1985年木脂素总摄入量的中位数为977微克/天。茶、蔬菜、面包、咖啡、水果和葡萄酒是木脂素的主要来源。木脂素总摄入量与死亡率无关。然而，罗汉松脂醇的摄入量与冠心病、心血管疾病及全因死亡率呈负相关（均P≤0.05），与癌症呈负相关（P = 0.06）。摄入量每增加1个标准差，经多变量调整后的率比（95%CI）分别为：冠心病0.72（0.53，0.98），心血管疾病0.83（0.69，1.00），全因死亡率0.86（0.76，0.97），癌症0.81（0.65，1.00）。
木脂素总摄入量与死亡率无关。罗汉松脂醇的摄入量与冠心病、心血管疾病、癌症及所有原因导致的死亡率呈负相关。我们不能排除罗汉松脂醇摄入量与死亡率之间的负相关是由一个相关因素引起的可能性，比如饮酒。
