Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA.
Breast Cancer Res Treat. 2010 Jul;122(1):229-35. doi: 10.1007/s10549-009-0681-x. Epub 2009 Dec 22.
Dietary lignan intakes have been associated with reduced breast cancer risks; however, no previous studies have investigated whether lignan intake might be associated with breast cancer survival. We examined the association of dietary lignan intakes with survival in 1122 women with primary, incident, histologically confirmed breast cancer identified between 1996 and 2001, and with vital status determined through December 31, 2006. Diet in the 12-24 months before diagnosis was assessed with an extensive food frequency questionnaire, and potential confounders assessed from an extensive epidemiologic interview and abstracted clinical data. Lignan intake was calculated using published food composition data. Hazard ratios (HR), and 95% confidence intervals (CIs) for dietary lignan intakes with all cause, and breast cancer mortality were estimated using Cox proportional hazards adjusting for age, education, race, total energy intake, tumor stage, and body mass index. Of the 1122 women with complete dietary data, 160 had died by the end of follow-up. Among postmenopausal women only, those in the highest versus lowest quartile of lignan intakes had a statistically significant reduction in the risk of all cause mortality (HR 0.49, 95% CI 0.26-0.91) and a significantly reduced risk of breast cancer mortality (HR 0.29, 95% CI 0.11-0.76). Higher intakes of dried beans (HR 0.61, 95% CI 0.36-1.03), but not fruits, vegetables, or grains, were also weakly associated with overall mortality. In summary, our results suggest that higher lignan intakes may be associated with improved survival among postmenopausal women with breast cancer.
饮食木脂素的摄入量与降低乳腺癌风险有关；然而，以前的研究没有调查木脂素的摄入量是否与乳腺癌的生存有关。我们研究了饮食木脂素摄入量与 1996 年至 2001 年间确诊的 1122 例原发性、偶发性、组织学确诊的乳腺癌女性的生存情况之间的关系，并通过 2006 年 12 月 31 日的生存状态来确定。在诊断前 12-24 个月的饮食情况通过一份广泛的食物频率问卷进行评估，潜在的混杂因素通过广泛的流行病学访谈和提取的临床数据进行评估。木脂素的摄入量是使用已发表的食物成分数据计算的。使用 Cox 比例风险模型调整年龄、教育程度、种族、总能量摄入、肿瘤分期和体重指数，估计所有原因和乳腺癌死亡率的膳食木脂素摄入量的风险比（HR）和 95%置信区间（CI）。在有完整饮食数据的 1122 名女性中，有 160 人在随访结束时死亡。仅在绝经后妇女中，木脂素摄入量最高与最低四分位数相比，全因死亡率的风险显著降低（HR 0.49，95%CI 0.26-0.91），乳腺癌死亡率的风险显著降低（HR 0.29，95%CI 0.11-0.76）。摄入更多的干豆（HR 0.61，95%CI 0.36-1.03），而不是水果、蔬菜或谷物，也与总体死亡率呈弱相关。总之，我们的结果表明，木脂素摄入量较高可能与绝经后乳腺癌女性的生存改善有关。
