Department of Food Biotechnology, Faculty of Health Sciences, Medical University of Bialystok, Szpitalna 37, 15-295 Bialystok, Poland.
Department of Epidemiology, Cardiovascular Disease Prevention and Health Promotion, Institute of Cardiology, Alpejska 42, 04-628 Warsaw, Poland.
Nutrients. 2018 Jul 4;10(7):865. doi: 10.3390/nu10070865.
The study objectives were to examine total and individual lignan intakes and their dietary sources in postmenopausal Polish women and to investigate the relationship between lignan intake and the prevalence of cardiovascular disease (CVD), hypertension, hypercholesterolemia and central obesity. A total of 2599 postmenopausal women, participants of the Multi-centre National Population Health Examination Surveys (WOBASZ and WOBASZ II) were selected. Of them, 916 had a history of CVD. Nutritional data were collected using a single 24-h dietary recall. Data on lignan content in food, i.e., lariciresinol (LARI), matairesinol (MAT), pinoresinol (PINO) and secoisolariciresinol (SECO), were collected from the available lignan databases. In postmenopausal women, total and individual lignan intakes (SECO, PINO, MAT) were not associated with the prevalence of CVD and its risk factors. The intake of LARI was linked by 30% to the reduced odds for hypercholestrolemia. This study reinforces the existing concept that dietary total lignans are not associated with the prevalence of CVD, and provides further evidence that they are not linked to CVD risk factors such as hypertension, hypercholesterolemia and central obesity. However, the intake of LARI should be taken into consideration in further studies with regard to its potentially beneficial effect in hypercholesterolemia.
本研究旨在探讨绝经后波兰女性木脂素的总摄入量和个体摄入量及其饮食来源，并研究木脂素摄入量与心血管疾病（CVD）、高血压、高胆固醇血症和中心性肥胖的患病率之间的关系。本研究共选取了 2599 名绝经后女性，这些女性均为多中心国家人口健康检查调查（WOBASZ 和 WOBASZ II）的参与者。其中，916 人有 CVD 病史。采用单一的 24 小时膳食回顾法收集营养数据。食物中木脂素含量的数据，即落叶松脂素（LARI）、马尾松脂素（MAT）、松脂醇（PINO）和橄榄树脂素（SECO），则来自现有的木脂素数据库。在绝经后女性中，木脂素的总摄入量和个体摄入量（SECO、PINO、MAT）与 CVD 及其危险因素的患病率无关。LARI 的摄入量与降低高胆固醇血症的几率相关，降低幅度为 30%。本研究进一步证实了现有概念，即膳食总木脂素与 CVD 的患病率无关，并提供了进一步的证据表明，它们与 CVD 的危险因素如高血压、高胆固醇血症和中心性肥胖无关。然而，在进一步研究中，应考虑 LARI 的摄入量，以研究其在高胆固醇血症方面的潜在有益作用。
