Martan A, Masata J, Petri E, Svabík K, Drahorádová P, Voigt R, Pavlíková M, Hlásenská J
Department of Obstetrics and Gynecology, Charles University, Apolinárská 18, 128 00, Prague 2, Czech Republic.
Int Urogynecol J Pelvic Floor Dysfunct. 2007 Mar;18(3):267-71. doi: 10.1007/s00192-006-0140-8. Epub 2006 Aug 5.
The aims of the present study were to find the correlation between Valsalva leak-point pressure (VLPP) and cough leak-point pressure (CLPP) and to determine whether the water perfusion maximum urethral closure pressure (MUCP) correlates with VLPP. Seventy-nine women with previously untreated stress urinary incontinence were recruited to participate in a clinical study. Their mean age was 56.4 years, mean BMI was 27.8, and mean parity was 1.9. The mean values of VLPP and CLPP were 50.4 and 52.9 cm H(2)O, respectively. We did not find statistically significant differences in the mean values of VLPP and CLPP. The mean value of MUCP at rest was 44.2 cm H(2)O and the mean value of MUCP during maximal Valsalva maneuver was 37.2 cm H(2)O; with 500 ml of sterile saline in the bladder the difference between them is statistically significant. In the study group (n=79), 56 patients (77%) had low VLPP (< or =60 cm H(2)O), 21 patients (30%) had low MUCP (< or =30 cm H(2)O), and 8 patients had MUCP< or =20 cm H(2)O (all at rest). Of the 56 patients with low VLPP, 16 also had a low MUCP (< or =30 cm H(2)O). This study mainly compares two parameters-the MUCP and the VLPP. Based on our results we can conclude that there is no correlation between these parameters. MUCP measures urethral resistance at rest and VLPP measures urethral resistance during increased intra-abdominal pressure (Valsalva maneuver).
本研究的目的是找出瓦尔萨尔瓦漏点压力（VLPP）与咳嗽漏点压力（CLPP）之间的相关性，并确定水灌注最大尿道闭合压力（MUCP）与VLPP是否相关。招募了79名既往未经治疗的压力性尿失禁女性参与一项临床研究。她们的平均年龄为56.4岁，平均体重指数为27.8，平均产次为1.9。VLPP和CLPP的平均值分别为50.4和52.9 cm H₂O。我们未发现VLPP和CLPP平均值存在统计学显著差异。静息时MUCP的平均值为44.2 cm H₂O，最大瓦尔萨尔瓦动作时MUCP的平均值为37.2 cm H₂O；膀胱内注入500 ml无菌生理盐水时，两者之间的差异具有统计学显著性。在研究组（n = 79）中，56例患者（77%）VLPP较低（≤60 cm H₂O），21例患者（30%）MUCP较低（≤30 cm H₂O），8例患者MUCP≤20 cm H₂O（均在静息时）。在56例VLPP较低的患者中，16例同时MUCP也较低（≤30 cm H₂O）。本研究主要比较了两个参数——MUCP和VLPP。根据我们的结果可以得出结论，这些参数之间不存在相关性。MUCP测量静息时的尿道阻力，VLPP测量腹内压升高（瓦尔萨尔瓦动作）时的尿道阻力。
