Ashikari Masayuki, Ozeki Hironori, Tomida Kazuyuki, Sakurai Eiji, Tamai Kazushi, Ogura Yuichiro
Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Science, Nagoya, Japan.
Jpn J Ophthalmol. 2006 Jul-Aug;50(4):349-353. doi: 10.1007/s10384-006-0325-1.
To evaluate dye retention in the fundus after indocyanine green (ICG)-assisted internal limiting membrane peeling.
Ten eyes with stage 3 or 4 nondiabetic idiopathic macular hole (MH group) and six eyes with diffuse diabetic macular edema (DM group) were studied. The fundus was examined with 780-nm infrared illumination by a scanning laser ophthalmoscope (SLO) after ICG-assisted internal limiting membrane peeling. The postoperative follow-up period ranged from 6 to 12 months (mean+/-SD, 3.7+/-2.6 months).
Fluorescence from ICG was detected in all studied eyes in both groups up to 6 months after surgery. At 9 months after surgery, ICG fluorescence was visible in all eyes of the DM group, but in only one-third of eyes of the MH group. No fluorescence was detected in fellow eyes that had not been operated on.
The present study using SLO revealed that ICG remains in the fundus for over 6 months after surgery. The results also suggested that a longer time might be required for dye clearance from the diabetic retina than from the nondiabetic retina.
评估吲哚菁绿（ICG）辅助内界膜剥除术后眼底的染料潴留情况。
研究了10只患有3期或4期非糖尿病性特发性黄斑裂孔的眼睛（MH组）和6只患有弥漫性糖尿病性黄斑水肿的眼睛（DM组）。在ICG辅助内界膜剥除术后，用扫描激光检眼镜（SLO）以780纳米红外光照射检查眼底。术后随访期为6至12个月（平均±标准差，3.7±2.6个月）。
两组所有研究的眼睛在术后6个月内均检测到ICG荧光。术后9个月时，DM组所有眼睛均可见ICG荧光，但MH组只有三分之一的眼睛可见。未手术的对侧眼未检测到荧光。
本研究使用SLO显示，ICG在术后眼底留存超过6个月。结果还表明，糖尿病视网膜清除染料所需的时间可能比非糖尿病视网膜更长。
