Rivas-Santiago Bruno, Sada Eduardo, Tsutsumi Victor, Aguilar-Leon Diana, Contreras Juan Leon, Hernandez-Pando Rogelio
Department of Microbiology Research, National Institute for Respiratory Diseases, National Institute of Medical Sciences and Nutrition Salvador Zubiran, Vasco de Quiroga 15, cp-14000, Tlalpan, Mexico City, Mexico.
J Infect Dis. 2006 Sep 1;194(5):697-701. doi: 10.1086/506454. Epub 2006 Jul 28.
The kinetics of gene expression and the cellular source of murine beta -defensin-3 (mBD3) and murine beta -defensin-4 (mBD4) were determined in mouse models of progressive pulmonary tuberculosis and latent infection induced by high or low infecting doses, respectively. During progressive disease, there was an initial rapid expression of both defensins by respiratory epithelial cells that correlated with temporary control of bacillary proliferation, but expression decreased during the later progressive phase of the disease. In latent infection, both defensins were expressed continuously, but they were suppressed after reactivation of the disease. Thus, mycobacterial infection induces the expression of mBD3 and mBD4, and both might participate in the control of mycobacterial growth.
在分别由高感染剂量和低感染剂量诱导的进行性肺结核和潜伏感染小鼠模型中，测定了小鼠β-防御素-3（mBD3）和小鼠β-防御素-4（mBD4）的基因表达动力学及细胞来源。在进行性疾病期间，呼吸道上皮细胞最初会快速表达这两种防御素，这与细菌增殖的暂时控制相关，但在疾病后期的进行性阶段表达会下降。在潜伏感染中，两种防御素持续表达，但在疾病重新激活后会受到抑制。因此，分枝杆菌感染会诱导mBD3和mBD4的表达，两者可能都参与了对分枝杆菌生长的控制。
