Shuford Jennifer A, Rouse Mark S, Piper Kerryl E, Steckelberg James M, Patel Robin
Department of Medicine, Division of Infectious Diseases, Mayo Clinic College of Medicine, Rochester, 55905, USA.
J Infect Dis. 2006 Sep 1;194(5):710-3. doi: 10.1086/506452. Epub 2006 Jul 28.
Candida albicans biofilms complicate the treatment of infected implanted intravascular devices because of decreased antifungal susceptibility. In our investigation, 48 rabbits with experimental central venous catheter C. albicans infection were equally allocated to a control arm or to receive amphotericin B deoxycholate or caspofungin treatment while undergoing systemic and intraluminal lock therapy for 7 days. C. albicans was cultured from catheters from all control rabbits, from 3 that received amphotericin B, and from 0 that received caspofungin. Differences in colony counts were detected between the control and amphotericin (P<.001) and control and caspofungin (P<.001) arms. Caspofungin may be useful in the treatment of C. albicans biofilm-associated intravascular catheter infections, which warrants further study.
白色念珠菌生物膜会使受感染的植入式血管内装置的治疗变得复杂，因为其抗真菌敏感性降低。在我们的研究中，48只患有实验性中心静脉导管白色念珠菌感染的兔子被平均分配到一个对照组，或者接受两性霉素B脱氧胆酸盐或卡泊芬净治疗，同时进行全身和腔内封管治疗7天。所有对照兔的导管中均培养出白色念珠菌，接受两性霉素B治疗的兔子中有3只导管培养出白色念珠菌，而接受卡泊芬净治疗的兔子导管中未培养出白色念珠菌。对照组与两性霉素组（P<0.001）以及对照组与卡泊芬净组（P<0.001）之间的菌落计数存在差异。卡泊芬净可能对治疗白色念珠菌生物膜相关的血管内导管感染有用，这值得进一步研究。
