卡泊芬净在导管封管浓度下可根除葡萄牙念珠菌和季也蒙念珠菌的成熟生物被膜。
Caspofungin at catheter lock concentrations eradicates mature biofilms of Candida lusitaniae and Candida guilliermondii.
作者信息
Simitsopoulou Maria, Kyrpitzi Daniela, Velegraki Aristea, Walsh Thomas J, Roilides Emmanuel
机构信息
Laboratory of Infectious Diseases, 3rd Department of Pediatrics, Faculty of Medicine, Aristotle University School of Health Sciences, Hippokration Hospital, Thessaloniki, Greece.
Mycology Research Laboratory, Microbiology Department, Medical School, National & Kapodistrian University of Athens, Athens, Greece.
出版信息
Antimicrob Agents Chemother. 2014 Aug;58(8):4953-6. doi: 10.1128/AAC.03117-14. Epub 2014 Jun 2.
Abstract
The antibiofilm activities of caspofungin, anidulafungin, micafungin, and liposomal amphotericin B were studied against Candida lusitaniae, Candida guilliermondii, and a Candida albicans control strain. While anidulafungin and micafungin (0.007 to 2,048 mg/liter) showed reduced activity against biofilms of both test species, caspofungin displayed concentration-dependent antibiofilm activity, reaching complete and persistent eradication at concentrations achievable during lock therapy (512 to 2,048 mg/liter, P < 0.05). Although liposomal amphotericin B strongly inhibited mature biofilms, it possessed lower antibiofilm activity than caspofungin (P < 0.05).
摘要
研究了卡泊芬净、阿尼芬净、米卡芬净和两性霉素B脂质体对葡萄牙念珠菌、季也蒙念珠菌和白色念珠菌对照菌株的抗生物膜活性。虽然阿尼芬净和米卡芬净（0.007至2048毫克/升）对两种受试菌种的生物膜活性降低，但卡泊芬净表现出浓度依赖性抗生物膜活性，在锁疗法可达到的浓度（512至2048毫克/升，P<0.05）下实现完全且持久的根除。虽然两性霉素B脂质体强烈抑制成熟生物膜，但其抗生物膜活性低于卡泊芬净（P<0.05）。
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