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表皮生长因子和转化生长因子-β对人、大鼠和小鼠培养肝细胞中白细胞介素-6引发的急性期反应有不同的调节作用。

Epidermal growth factor and transforming growth factor-beta differently modulate the acute phase response elicited by interleukin-6 in cultured liver cells from man, rat and mouse.

作者信息

Rokita H, Bereta J, Koj A, Gordon A H, Gauldie J

机构信息

Institute of Molecular Biology, Jagiellonian University, Krakow, Poland.

出版信息

Comp Biochem Physiol A Comp Physiol. 1990;95(1):41-5. doi: 10.1016/0300-9629(90)90007-f.

DOI:10.1016/0300-9629(90)90007-f
PMID:1690099
Abstract
  1. Complex effects of principal inflammatory cytokines (IL-6, IL-1, TNF, IFN-gamma) on acute phase protein synthesis and other metabolic processes in cultured liver cells are briefly reviewed. 2. Molecular properties and biological functions of transforming growth factor-beta and epidermal growth factor are compared. 3. The effects of these factors with respect to both amino acid uptake and acute phase protein synthesis are described in detail. The results are found to be different for rat or mouse hepatocytes and human hepatoma cells.
摘要
  1. 简要综述了主要炎性细胞因子(白细胞介素-6、白细胞介素-1、肿瘤坏死因子、γ-干扰素)对培养肝细胞中急性期蛋白合成及其他代谢过程的复杂影响。2. 比较了转化生长因子-β和表皮生长因子的分子特性与生物学功能。3. 详细描述了这些因子在氨基酸摄取和急性期蛋白合成方面的作用。结果发现,大鼠或小鼠肝细胞与人肝癌细胞的情况有所不同。

相似文献

1
Epidermal growth factor and transforming growth factor-beta differently modulate the acute phase response elicited by interleukin-6 in cultured liver cells from man, rat and mouse.表皮生长因子和转化生长因子-β对人、大鼠和小鼠培养肝细胞中白细胞介素-6引发的急性期反应有不同的调节作用。
Comp Biochem Physiol A Comp Physiol. 1990;95(1):41-5. doi: 10.1016/0300-9629(90)90007-f.
2
Transforming growth factor-beta and epidermal growth factor modulate basal and interleukin-6-induced amino acid uptake and acute phase protein synthesis in cultured rat hepatocytes.转化生长因子-β和表皮生长因子调节培养大鼠肝细胞中基础状态下以及白细胞介素-6诱导的氨基酸摄取和急性期蛋白合成。
FEBS Lett. 1990 Jun 18;266(1-2):48-50. doi: 10.1016/0014-5793(90)81503-g.
3
Role of cytokines and growth factors in the induced synthesis of proteinase inhibitors belonging to acute phase proteins.细胞因子和生长因子在诱导合成属于急性期蛋白的蛋白酶抑制剂中的作用。
Biomed Biochim Acta. 1991;50(4-6):421-5.
4
Interleukin-6 production by human liver (myo)fibroblasts in culture. Evidence for a regulatory role of LPS, IL-1 beta and TNF alpha.培养的人肝(肌)成纤维细胞产生白细胞介素-6。脂多糖、白细胞介素-1β和肿瘤坏死因子α调节作用的证据。
J Hepatol. 1995 Sep;23(3):295-306.
5
Effects of interleukin-6 and leukemia inhibitory factor on the acute phase response and DNA synthesis in cultured rat hepatocytes.白细胞介素-6和白血病抑制因子对培养大鼠肝细胞急性期反应及DNA合成的影响。
Lymphokine Cytokine Res. 1991 Apr;10(1-2):23-6.
6
Pig MAP/ITIH4 and haptoglobin are interleukin-6-dependent acute-phase plasma proteins in porcine primary cultured hepatocytes.猪的MAP/ITIH4和触珠蛋白是猪原代培养肝细胞中依赖白细胞介素-6的急性期血浆蛋白。
Eur J Biochem. 2000 Mar;267(6):1878-85. doi: 10.1046/j.1432-1327.2000.01195.x.
7
Regulation of acute phase reaction by transforming growth factor beta in cultured murine hepatocytes.转化生长因子β对培养的小鼠肝细胞急性期反应的调节作用
Acta Biochim Pol. 1991;38(2):241-9.
8
Effects of cytokines and growth factors on phosphorylated fetuin biosynthesis by adult rat hepatocytes in primary culture.细胞因子和生长因子对原代培养的成年大鼠肝细胞磷酸化胎球蛋白生物合成的影响。
Biochem Biophys Res Commun. 1994 Apr 15;200(1):598-605. doi: 10.1006/bbrc.1994.1490.
9
Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes.白细胞介素-6是成人肝细胞中急性期蛋白合成的主要调节因子。
FEBS Lett. 1989 Jan 2;242(2):237-9. doi: 10.1016/0014-5793(89)80476-4.
10
Action of recombinant human interleukin 6, interleukin 1 beta and tumor necrosis factor alpha on the mRNA induction of acute-phase proteins.重组人白细胞介素6、白细胞介素1β和肿瘤坏死因子α对急性期蛋白mRNA诱导的作用。
Eur J Immunol. 1988 May;18(5):739-46. doi: 10.1002/eji.1830180513.

引用本文的文献

1
Effect of recombinant human interleukin 1β (rhIL-1β) on amino acid flux in the isolated perfused rat liver.重组人白介素 1β(rhIL-1β)对离体灌流大鼠肝脏氨基酸通量的影响。
Amino Acids. 1992 Jun;3(2):139-46. doi: 10.1007/BF00806779.