转化生长因子-β和表皮生长因子调节培养大鼠肝细胞中基础状态下以及白细胞介素-6诱导的氨基酸摄取和急性期蛋白合成。
Transforming growth factor-beta and epidermal growth factor modulate basal and interleukin-6-induced amino acid uptake and acute phase protein synthesis in cultured rat hepatocytes.
作者信息
Bereta J, Szuba K, Fiers W, Gauldie J, Koj A
机构信息
Institute of Molecular Biology, Jagiellonian University, Krakow, Poland.
出版信息
FEBS Lett. 1990 Jun 18;266(1-2):48-50. doi: 10.1016/0014-5793(90)81503-g.
Rat hepatocytes cultured for 2 days with interleukin-6 show increased synthesis of acute phase proteins and enhanced accumulation of 14C-labelled alpha-aminoisobutyric acid. Transforming growth factor-beta 1 (0.1-10 ng/ml) inhibits whereas epidermal growth factor (1-100 ng/ml) enhances both basal and interleukin-6-induced amino acid uptake by rat hepatocytes with only a slight alteration of acute phase protein synthesis.
用白细胞介素-6培养2天的大鼠肝细胞显示急性期蛋白合成增加，且14C标记的α-氨基异丁酸积累增强。转化生长因子-β1（0.1 - 10 ng/ml）起抑制作用，而表皮生长因子（1 - 100 ng/ml）在仅轻微改变急性期蛋白合成的情况下，增强大鼠肝细胞的基础及白细胞介素-6诱导的氨基酸摄取。
Zotero 插件