Wright R A, O'Conner K W
Division of Gastroenterology, University of Louisville School of Medicine, Kentucky 40292.
Gastrointest Endosc. 1990 Jan-Feb;36(1):47-8. doi: 10.1016/s0016-5107(90)70922-4.
In a pilot study of five patients with advanced esophageal squamous cell carcinoma, a solution of 5 fluorouracil (25 mg/ml) and sodium morrhuate (2.5%) was injected endoscopically with a sclerotherapy catheter directly into the tumor to determine whether tumor debulking could be achieved. Tissue necrosis was apparent in three patients who had not had prior radiation or chemotherapy, but the effect lasted less than 1 month despite injections at 3- to 7-day intervals. Patients who had prior radiation treatment had tumors too firm and fibrotic to inject effectively.
在一项针对5例晚期食管鳞状细胞癌患者的试点研究中，通过硬化疗法导管在内镜下将5-氟尿嘧啶溶液（25毫克/毫升）和鱼肝油酸钠溶液（2.5%）直接注射到肿瘤中，以确定是否能够实现肿瘤减容。在3例未曾接受过放疗或化疗的患者中，出现了明显的组织坏死，尽管每隔3至7天进行一次注射，但效果持续不到1个月。曾接受过放疗的患者，其肿瘤质地过硬且纤维化严重，无法有效注射。
