新型苯并环庚酮恶唑烷酮类抗菌剂的合成及构效关系研究
Synthesis and structure-activity studies of novel benzocycloheptanone oxazolidinone antibacterial agents.
作者信息
Vara Prasad J V N, Boyer Frederick E, Chupak Lou, Dermyer Michael, Ding Qizhu, Gavardinas K, Hagen Susan E, Huband Michael D, Jiao Wenhua, Kaneko Takushi, Maiti Samarendra N, Melnick Michael, Romero Karina, Patterson M, Wu Xiujuan
机构信息
Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA.
出版信息
Bioorg Med Chem Lett. 2006 Oct 15;16(20):5392-7. doi: 10.1016/j.bmcl.2006.07.064. Epub 2006 Aug 9.
PMID:16901693
Abstract
We describe a novel class of benzocycloheptanone derived oxazolidinone antibacterial agents. The synthesis and antibacterial activities with structure variation is discussed.
摘要
我们描述了一类新型的源自苯并环庚酮的恶唑烷酮类抗菌剂。讨论了其合成方法以及结构变化对抗菌活性的影响。
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