神经性厌食症中的转换能力缺陷。
Set shifting deficit in anorexia nervosa.
作者信息
Steinglass Joanna E, Walsh B Timothy, Stern Yaakov
机构信息
Department of Psychiatry, College of Physicians & Surgeons of Columbia University, and The New York State Psychiatric Institute, New York, New York, USA.
出版信息
J Int Neuropsychol Soc. 2006 May;12(3):431-5. doi: 10.1017/s1355617706060528.
Anorexia nervosa (AN) is a severe mental illness characterized in part by rigid thinking and ritualized behaviors involving eating and weight. Cognitive rigidity may play a role in the perpetuation of symptoms, and may provide information as to important brain-based abnormalities. Neuropsychological studies of patients with AN have shown cognitive dysfunction, but few have focused on cognitive flexibility. This study assessed set shifting in patients with AN, as a measure of cognitive flexibility. In this study, 15 patients with AN were compared with 11 healthy controls using a neuropsychological battery including the Wisconsin Card Sort Test (WCST). While patients with AN did not differ from controls on 5 measures of neuropsychological function, they made significantly more perseverative errors on the WCST, indicating a problem in set shifting. This finding suggests that patients with AN have a specific neurocognitive abnormality that may play a role in the development and persistence of this disorder.
神经性厌食症（AN）是一种严重的精神疾病，其部分特征是思维僵化以及涉及饮食和体重的仪式化行为。认知僵化可能在症状的持续存在中起作用，并且可能为重要的基于大脑的异常情况提供信息。对神经性厌食症患者的神经心理学研究显示出认知功能障碍，但很少有研究关注认知灵活性。本研究评估了神经性厌食症患者的定势转换，以此作为认知灵活性的一种测量方法。在本研究中，使用包括威斯康星卡片分类测验（WCST）在内的神经心理成套测验，将15名神经性厌食症患者与11名健康对照者进行了比较。虽然神经性厌食症患者在5项神经心理功能测量指标上与对照组没有差异，但他们在WCST上出现了显著更多的持续性错误，这表明在定势转换方面存在问题。这一发现表明，神经性厌食症患者存在特定的神经认知异常，这可能在该疾病的发展和持续存在中起作用。
Zotero 插件